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Atherosclerosis, 1998
The current study compared the acute effect of human apolipoprotein (apo) E isoforms on plasma lipids, lipoproteins and apolipoproteins 6 h after a bolus intravenous injection of individual isoforms into apo E-deficient mice.
Jiana Yuan +2 more
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The current study compared the acute effect of human apolipoprotein (apo) E isoforms on plasma lipids, lipoproteins and apolipoproteins 6 h after a bolus intravenous injection of individual isoforms into apo E-deficient mice.
Jiana Yuan +2 more
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Apolipoprotein E polymorphism and gallstones
Gastroenterology, 1996Apolipoprotein (apo) E is a genetically polymorphic protein influencing lipoprotein metabolism and the risk of both atherosclerosis and Alzheimer's disease. As opposed to common apo E3, apo E2 decreases and apo E4 increases hepatic lipoprotein uptake; hence, apo E4 could promote gallstone formation by increasing hepatic and biliary cholesterol ...
C Sanllehy +9 more
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Apolipoprotein E and Alzheimer disease
Neurology, 2006Apolipoprotein (apo) E, a multifunctional protein with central roles in lipid metabolism and neurobiology, has three common isoforms (apoE2, apoE3, and apoE4) with different effects on lipid homeostasis and neurobiology. Unlike apoE3, the most common isoform, apoE4, is associated with increased risk of developing Alzheimer disease (AD) and other ...
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Apolipoprotein E genotype and psychosis
Biological Psychiatry, 1997Apolipoprotein E (Apo E) is a protein with 299 amino acids coded by a gene on chromosome 19. The three major isoforms of Apo E (Apo E2, Apo E3, and Apo E4) are products of three alleles (Apo E-e2, Apo E-e3, and Apo E-e4). Inheriting the e4 allele of the Apo E is associated with increased risk of developing Alzheimer's disease (AD).
Shoichi Katsuragi +7 more
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Future Lipidology, 2008
Apolipoprotein E4 is a risk factor for developing Alzheimer’s disease (AD) at an earlier age. Anxiety is most common in AD patients with an age-at-onset under 65 years old. We hypothesize that differential effects of human ApoE isoforms on anxiety contribute to this effect.
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Apolipoprotein E4 is a risk factor for developing Alzheimer’s disease (AD) at an earlier age. Anxiety is most common in AD patients with an age-at-onset under 65 years old. We hypothesize that differential effects of human ApoE isoforms on anxiety contribute to this effect.
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Apolipoprotein E and cognitive performance
Nature, 2000Key proteins implicated in the development of Alzheimer's disease are the β-amyloid precursor protein, which gives rise to the β-amyloid peptides that accumulate in the deteriorating brain1,2, and the different isoforms of apolipoprotein E (apoE). The apoE4 variant increases the risk of developing the disease compared with apoE3 (ref. 3).
Jacob Raber +6 more
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Polymorphism of Apolipoprotein E
1980Plasma cholesterol levels are under multifactorial control. Environmental as well as genetic factors contribute to the considerable variance of cholesterol concentrations within and in between populations. Individual genes responsible for the normal variance of cholesterol in plasma have however not yet been identified.
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The Role of Apolipoprotein E and Apolipoprotein B in Atherosclerosis
1991Two apolipoproteins (apo-), apo-B100 and apo-E, are extremely important in lipoprotein metabolism and in the development of accelerated atherosclerosis. Their significance stems from their role in binding to the low density lipoprotein (LDL) receptor and mediating the catabolism of lipoproteins via the LDL receptor pathway.
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