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Glucuronidation of apomorphine [PDF]
Life Sciences, 2000 Apomorphine, a dopaminergic receptor agonist, is largely used in the therapy of Parkinson's disease. In this study, we characterized the glucuronidation of apomorphine and other catechols in rat liver and brain microsomes, using UDP-[U-14C]glucuronic acid and separation of the glucuronides formed by a thin layer chromatographic method.
R S, El-Bachá +4 more
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Enhancement of transdermal apomorphine delivery with a diester prodrug strategy [PDF]
European Journal of Pharmaceutics and Biopharmaceutics, 2011 Diester prodrugs of apomorphine, diacetyl apomorphine (DAA), and diisobutyryl apomorphine (DIA), were synthesized, and their partition coefficients, capacity factor (log K'), enzymatic hydrolysis, and in vitro permeation across nude mouse skin were ...
Chin-Chen Chu +2 more
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Pharmacology and Neurochemistry of Apomorphine
1978Publisher Summary This chapter discusses the pharmacology and neurochemistry of apomorphine. Apomorphine was first employed as a powerful emetic agent. Apomorphine can be obtained by the acid-catalyzed rearrangement of morphine and by total synthesis.
DI CHIARA, GAETANO, GESSA GL
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