Results 271 to 280 of about 1,705,451 (305)
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Apoptosis, 2001
The TP53 tumour-suppressor gene belongs to a family that includes the two recently identified homologues TP63 and TP73. Overexpression of p73 can activate typical p53-responsive genes and induce apoptosis like p53. In addition, activation of p73 has been implicated in apoptotic cell death induced by aberrant cell proliferation and some forms of DNA ...
T, Stiewe, B M, Pützer
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The TP53 tumour-suppressor gene belongs to a family that includes the two recently identified homologues TP63 and TP73. Overexpression of p73 can activate typical p53-responsive genes and induce apoptosis like p53. In addition, activation of p73 has been implicated in apoptotic cell death induced by aberrant cell proliferation and some forms of DNA ...
T, Stiewe, B M, Pützer
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Nature, 2000
Essential to the construction, maintenance and repair of tissues is the ability to induce suicide of supernumerary, misplaced or damaged cells with high specificity and efficiency. Study of three principal organisms--the nematode, fruitfly and mouse--indicate that cell suicide is implemented through the activation of an evolutionarily conserved ...
P, Meier, A, Finch, G, Evan
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Essential to the construction, maintenance and repair of tissues is the ability to induce suicide of supernumerary, misplaced or damaged cells with high specificity and efficiency. Study of three principal organisms--the nematode, fruitfly and mouse--indicate that cell suicide is implemented through the activation of an evolutionarily conserved ...
P, Meier, A, Finch, G, Evan
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Microbes and Infection, 2018
Apoptosis is one of the principal responses that human cells have at their disposal when faced with changes in their environment. Microbial infection is a massive challenge to a cell, and it is unsurprising that the apoptosis apparatus has been implicated in numerous infections.
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Apoptosis is one of the principal responses that human cells have at their disposal when faced with changes in their environment. Microbial infection is a massive challenge to a cell, and it is unsurprising that the apoptosis apparatus has been implicated in numerous infections.
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Annual Review of Microbiology, 1999
▪ Abstract Successful viral replication requires not only the efficient production and spread of progeny, but also evasion of host defense mechanisms that limit replication by killing infected cells. In addition to inducing immune and inflammatory responses, infection by most viruses triggers apoptosis or programmed cell death of the infected cell ...
A, Roulston +2 more
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▪ Abstract Successful viral replication requires not only the efficient production and spread of progeny, but also evasion of host defense mechanisms that limit replication by killing infected cells. In addition to inducing immune and inflammatory responses, infection by most viruses triggers apoptosis or programmed cell death of the infected cell ...
A, Roulston +2 more
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2010
During ageing the immune system is characterized by a peculiar remodelling, called immunosenescence. Apoptosis or programmed cell death plays a central role in this process. Both recurrent antigenic stimulations and oxidative metabolism byproducts, impinging upon the immune system, modify the apoptotic capability of lymphocytes, driving ...
GINALDI, Lia +1 more
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During ageing the immune system is characterized by a peculiar remodelling, called immunosenescence. Apoptosis or programmed cell death plays a central role in this process. Both recurrent antigenic stimulations and oxidative metabolism byproducts, impinging upon the immune system, modify the apoptotic capability of lymphocytes, driving ...
GINALDI, Lia +1 more
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BioEssays, 1997
AbstractApoptosis is an essential part of the normal cellular phenotype repertoire. In the absence of appropriate survival factors, apoptosis is activated through specific signalling cassettes. Epithelia form distinctive three‐dimensional cohesive structures that depend on adhesive interactions in order for these tissues to carry out their specialised ...
Metcalfe, Anthony, Streuli, C.H.
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AbstractApoptosis is an essential part of the normal cellular phenotype repertoire. In the absence of appropriate survival factors, apoptosis is activated through specific signalling cassettes. Epithelia form distinctive three‐dimensional cohesive structures that depend on adhesive interactions in order for these tissues to carry out their specialised ...
Metcalfe, Anthony, Streuli, C.H.
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Apoptosis in glomerulonephritis
Current Opinion in Nephrology & Hypertension, 2005Although glomerular cell apoptosis may be detrimental in acute and chronic inflammation, it is also a key component of the reparative glomerular remodelling that can follow injury. All glomerular cells are vulnerable to apoptosis although there are often differences in the nature of the initiating stimulus and the factors that are protective.
Jeremy, Hughes, John S, Savill
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Trends in Pharmacological Sciences, 1999
Apoptosis is an area of intense scientific interest, which encompasses the study of and triggers mechanisms involved in mediating the cell biology of programmed cell death. A number of low molecular weight compounds have been used to inhibit or enhance this fundamental cellular process and so apoptosis has now become amenable to pharmacological ...
R A, Kinloch +3 more
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Apoptosis is an area of intense scientific interest, which encompasses the study of and triggers mechanisms involved in mediating the cell biology of programmed cell death. A number of low molecular weight compounds have been used to inhibit or enhance this fundamental cellular process and so apoptosis has now become amenable to pharmacological ...
R A, Kinloch +3 more
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1998
The cell dying by apoptosis undergoes a sequence of morphological, biochemical, and molecular changes which are characteristic, and often unique, to this mode of cell death. Specific features of apoptotic cells resulting from these changes, which serve as markers used to reveal the apoptotic mode of cell death and to quantify the extent of apoptosis in
Z, Darzynkiewicz, F, Traganos
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The cell dying by apoptosis undergoes a sequence of morphological, biochemical, and molecular changes which are characteristic, and often unique, to this mode of cell death. Specific features of apoptotic cells resulting from these changes, which serve as markers used to reveal the apoptotic mode of cell death and to quantify the extent of apoptosis in
Z, Darzynkiewicz, F, Traganos
openaire +2 more sources