Results 131 to 140 of about 997,762 (284)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

"A custome lothsome": Investigating the association between tobacco consumption and respiratory inflammation in two post-medieval English populations (c. CE 1500-1855).

PLoS ONE
Despite current clinical knowledge of the risks associated with tobacco consumption, the bioarchaeological investigation of tobacco's effect on health in past populations remains woefully underexamined.
Anna M Davies-Barrett, Maia Casna, Sarah A Inskip   +2 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Economic Living Standard Indices mediate the apparent health benefits of alcohol consumption among older adults.

, 2013
Considerable population health research suggests that alcohol may have beneficial effects on physical health and mortality rates. This “healthy-dose” finding persists when controlling for potential confounds (e.g., age, gender, income). We explored the degree to which economic living standards further contribute to our understandings of how alcoholic ...
Philipp, Michael, Towers, Andy
openaire   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Elucidating the isotopic dynamics of nitrate and ammonium in the Fuji River using a Lagrangian approach: stable nitrate and fractionating ammonium

Progress in Earth and Planetary Science
Isotopic signatures (δ 15N and δ 18O) of nitrate (NO3 −) have been widely used to trace NO3 − sources in rivers. These isotopic markers are often treated as “conservative tracers,” reflecting source mixing without significant isotope fractionation.
Công Thuận Nguyễn, Tomoya Iwata, Yuta Ikeda, Midori Yano, Akiko Makabe, Keisuke Koba   +5 more
doaj   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Apparent Mineralocorticoid Excess due to daily consumption of liquorice - containing tea [PDF]

Endocrine Abstracts, 2016
Isolda Frizelle, Domnhal J. O'Halloran, Mohammed Sohail Anjum   +2 more
openaire   +1 more source

Pengaruh Pemasangan Kapasitor Shunt Terhadap Konsumsi Daya Aktif Instalasi Listrik

Dinamika Rekayasa, 2007
The application of shunt capacitor is an alternative solution in improving power factor on electrical installations, so the use of electric energy become more efficient.
Winasis Winasis, Azis Wisnu Widhi Nugraha   +1 more
doaj  

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source