Results 121 to 130 of about 1,203,677 (298)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Habitat-dependent effect of a rare predator on apparent survival of male Black-headed Bunting

Avian Conservation and Ecology, 2016
Both habitat changes and predation can cause population declines in farmland birds. Habitat changes may allow novel or invasive alien predators to establish populations in new environments, which can have major ecological consequences for native prey ...
Jelena Kralj, Sanja Barišić, Vesna Tutiš, Davor Ćiković, Herbert Hoi   +4 more
doaj   +1 more source

Kittens in the Oven: Race Relations, Traumatic Memory, and the Search for Identity in Julia Alvarez’s \u3cem\u3eHow the García Girls Lost Their Accents\u3c/em\u3e [PDF]

, 2010
The search for an ever-elusive home is a thread that runs throughout much literature by authors who have immigrated to the United States. Dominican authors are particularly susceptible to this search for a home because “for many Dominicans, home is ...
Carter, Natalie
core   +1 more source

Apparent survival, growth rate and dispersal in a declining European Roller population

Journal of Ornithology, 2019
Studying demographic parameters and how they may influence population growth is critical to the development of meaningful conservation actions for endangered species. The European Roller Coracias garrulus has experienced a drastic decline through its breeding distribution range, but very little is known about its demography (i.e. dispersal and survival)
Juan Rodríguez-Ruiz, Mónica Expósito-Granados, Jesús M. Avilés, Deseada Parejo   +3 more
openaire   +2 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Interaction of Gα₁₂ with Gα₁₃ and Gα_q signaling pathways [PDF]

, 2002
The G(12) subfamily of heterotrimeric G-proteins consists of two members, G(12) and G(13). Gene-targeting studies have revealed a role for G(13) in blood vessel development. Mice lacking the a subunit of G(13) die around embryonic day 10 as the result of
Gu, Jennifer L., Mancino, Valeria, Müller, Stefan, Offermanns, Stefan, Simon, Melvin I.   +4 more
core  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Hubble Space Telescope Observations of 3200 Phaethon At Closest Approach

, 2018
We present Hubble Space Telescope observations of the active asteroid (and Geminid stream parent) 3200 Phaethon when at its closest approach to Earth (separation 0.07 AU) in 2017 December.
Agarwal, Jessica, Jewitt, David, Li, Jing, Mutchler, Max   +3 more
core   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source