A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Survival costs of reproduction are independent of energy costs in a seabird, the pelagic cormorant
Ecology and EvolutionLife‐history theory predicts that investment in reproduction should decrease survival (the ‘cost of reproduction’). It is often assumed that energy allocation drives such trade‐offs, with limited energy available for both reproduction and survival ...
Téo Barracho +6 more
doaj +1 more source
Performance of a magnetic resonance imaging-based radiomics score combined with apparent diffusion coefficient in predicting hepatocellular carcinoma recurrence and disease-free survival: a retrospective cohort study [PDF]
E N Zengin +3 more
openalex +1 more source
Alteration of apparent diffusion coefficient measurements predict survival outcomes during neoadjuvant chemoradiotherapy in locally advanced rectal cancer [PDF]
, 2023 Yuma Wada +8 more
openalex +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Body size constrains the annual apparent survival of lekking Great Snipe Gallinago media males of eastern, lowland population [PDF]
, 2023 Marta Witkowska +3 more
openalex +1 more source
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Texture Analysis of the Apparent Diffusion Coefficient Focused on Contrast-Enhancing Lesions in Predicting Survival for Bevacizumab-Treated Patients with Recurrent Glioblastoma [PDF]
, 2023 Antonio López‐Rueda +10 more
openalex +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Reduced Adult Survival Estimated in Areas of Decline of Harbour Seal Populations in Scotland
Ecology and EvolutionUnderstanding the demographic drivers behind observed changes in wild populations is key to inferring intrinsic and extrinsic causes behind such changes. In Scotland, harbour seal populations have undergone regional declines since the early 2000s.
M. Arso Civil +13 more
doaj +1 more source