Results 111 to 120 of about 4,415,064 (273)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Automation of conceptual design and modification of aircraft type unmanned aerial vehicles using multidisciplinary optimization and evolutionary algorithms. Part 1: Methods and models

Вестник Самарского университета: Аэрокосмическая техника, технологии и машиностроение
This paper proposes a method for selecting rational parameters for large-size aircraft-type unmanned aerial vehicles at the initial design stages using an optimization algorithm of differential evolution and numerical mathematical modeling of aerodynamic
V. A. Komarov, O. E. Lukyanov, V. H. Hoang, E. I. Kurkin, J. G. QuijadaPioquinto   +4 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Organoleptic profiling for demand led breeding of eggplant (Solanum melongena L.) suitable for Kerala market

Electronic Journal of Plant Breeding
In order to develop eggplant hybrids with consumer acceptance, an organoleptic evaluation of fruits in two different sets of eggplant genotypes was conducted by a panel of 15 judges with 21 descriptors, following a quantitative descriptive analysis (QDA).
Kasireddy Sivasankarreddy1, Jiji Joseph1* and P. P. Thirumalaisamy2
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Development of almond flour bread recipe

Новые технологии
The industry of bakery products that do not contain gluten has not been studied enough, so this topic is gaining popularity among scientists. The subject of the study was the development of a bread recipe using almond flour.
E. S. Smirnova, E. V. Razhina, N. L. Lopaeva, I. M. Khairova, V. N. Sinko, A. V. Shilovtsev   +5 more
doaj   +1 more source

THE APPEARANCE OF CONSCIOUSNESS IN MACHINES [PDF]

This is merely the longish abstract of a talk I gave in 2001, that now seems to make more sense than ...
Sander, Desmond
core  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Prolegomenon for an ethics of visibility in Hannah Arendt

Kriterion
This paper aims to discuss the Arendtian notions of appearance and perception in order to promote a displacement of those conceptions from the generally associated domain of passive apprehension of the faculty of knowledge towards the domain of a ...
Bethânia Assy
doaj