Results 101 to 110 of about 2,191,893 (284)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

The comments of voices on the appearance of patients with psychosis: ‘the voices tell me that I am ugly’

BJPsych Open, 2019
BackgroundThere are high rates of obesity and low self-esteem in patients with psychosis. The occurrence of negative voice content directly about appearance is therefore plausible.
Felicity Waite, Rowan Diamond, Nicola Collett, Eleanor Chadwick, Emily Bold, Ashley-Louise Teale, Kathryn M. Taylor, Miriam Kirkham, Eve Twivy, Chiara Causier, Lydia Carr, Jessica C. Bird, Emma Černis, Louise Isham, Daniel Freeman   +14 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Four novel mutations identification in 17 beta-hydroxysteroid dehydrogenase-3 deficiency and our clinical experience: possible benefits of early treatment

Frontiers in Endocrinology
IntroductionIndividuals with 17-beta-hydroxysteroid dehydrogenase type 3 (17β-HSD3) deficiency face a multitude of challenges, primarily concerning genital appearance, potential malignancy risks, and fertility issues. This study reports our findings from
Yunpeng Wang, Yunpeng Wang, Yunpeng Wang, Yunpeng Wang, Yu Xu, Yu Xu, Yu Xu, Huijiao Zhang, Huijiao Zhang, Danyang Yin, Yiming Pan, Xiwen He, Xiwen He, Shuaiting Li, Zhi Cheng, Gaohui Zhu, Gaohui Zhu, Ting Zhao, Ting Zhao, Huizhe Huang, Min Zhu, Min Zhu, Min Zhu   +22 more
doaj   +1 more source

Retraction: Unmasking anxiety and appearance concerns: An examination using body dysmorphic concerns and body appearance shame

Stress Science Research, 2022
Tomohiro Suzuki, Mikako Yazawa
openaire   +1 more source

The Influences of Appearance Concern and Body Satisfaction on the Appearance Management Behavior of Male College Students

The Research Journal of the Costume Culture, 2011
Abstract The purpose of this study was to investigate the influences of appearance concern and body satisfaction on the appearance management behavior of male college students. For data collection, a questionnaire was administrated to 538 male college students in Gwangju city, Korea, from June 1 to June 20, 2011.
null 박혜원, null ChungMyungSun
openaire   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The psychosocial impact of alopecia in men: A mixed‐methods survey study

Skin Health and Disease
Background The most common forms of hair loss in men, alopecia areata (AA) (an autoimmune condition) and androgenetic alopecia (AGA) (pattern baldness), alter individuals' appearance in ways that may impact psychological and social wellbeing.
Fabio Zucchelli, Abbi Mathews, Nick Sharratt, Kerry Montgomery, Jen Chambers   +4 more
doaj   +1 more source