Results 121 to 130 of about 2,191,893 (284)

Appearance Concerns and Psychological Distress Among HIV-Infected Individuals with Injection Drug Use Histories: Prospective Analyses

, 2012
Morphologic alterations in body composition are common among HIV-infected individuals, and these changes are associated with increased appearance concerns. Previous cross-sectional data indicate that appearance concerns among HIV-infected individuals are
Gordon, Janna R, Safren, Steven A, Aaron J. Blashill, Janna R. Gordon, Blashill, Aaron J, Steven A. Safren   +5 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

A Pilot Study of a Gamified CBT-Based Digital Approach for Body Image Distress and Appearance-Related Concerns

Human Behavior and Emerging Technologies
Body image concerns related to perceived flaws in appearance represent a significant mental health challenge affecting a broad population. While Cognitive Behavioral Therapy (CBT) is an effective approach, stigma, financial costs, and limited access to ...
Anushka Singh, Naman Tyagi, Fahad Eqbal, Dolly Sharma, Aikaterini Bourazeri   +4 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Early appearance concerns after burns: Investigating the roles of psychological flexibility and self-compassion [PDF]

Few qualitative studies have explored appearance concerns soon after burn injuries. This study aimed to understand the early experiences of appearance concerns after burns, through the lens of psychological flexibility and self-compassion.
Thompson, Andrew R., Harcourt, Diana, Norman, Paul, Sirois, Fuschia, Shepherd, Laura   +4 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Associations of social media validation seeking with appearance anxiety, perceived stress and self-esteem in Indian adolescents and adults

Discover Public Health
Context Social media validation-seeking has emerged as a significant risk factor for body image disturbances and diminished psychological well-being among adolescents and adults, particularly in rapidly digitizing societies like India. While social media
Parth Singh Meena, Jayesh Alwani, Ayush Maurya, Anubhuti Sharma, Prem Prakash   +4 more
doaj   +1 more source

Lesbian, gay, bisexual and trans appearance and embodiment : a critical review of the psychological literature [PDF]

, 2012
This paper provides a review of the psychological literature on LGBT appearance and embodiment. Research on ‘outsider’ perceptions of LGBT appearance and embodiment has focused on the links between perceptions of physical attractiveness and homosexuality,
Huxley, Caroline, Clarke, Victoria, Huxley, Caroline J., Hayfield, Nikki   +3 more
core  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source