Results 61 to 70 of about 8,283 (304)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
OENO One, 1987 L'application de l'analyse multidimensionnelle des données à la reconnaissance des vins de trois appellations de la Rioja, permet de choisir huit variables physico-chimiques, facilement accessibles, comme étant hautement significatives.
Rosa M. Tapias +4 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Russian Journal of Economics and Law, 2014 Objective: basing on the studies of the formation and development of appellation procedure in Russian law, used for verification of court judgments in the Russian criminal procedure, as well as on comparative historical and legal analysis of this ...
A. A. Yunusov, N. N. Mazina
doaj
Un vignoble en quête de terroir. Construction et mise en place des AOC dans le vignoble nantais
Territoires du Vin, 2009 Le vignoble nantais a connu à l’Epoque Moderne une phase de recherche qualitative, avant d’être réorienté vers la production de petits vins. Un vignoble de masse se développe au XIXe siècle.
Raphaël Schirmer
doaj +1 more source
Bordeaux 2019 by appellation: Margaux
, 2020 contribution à un site webOverall, 2019 is a relatively homogenous vintage – with no great qualitative difference between left and right bank nor really between appellations.
Hay, Colin
core
Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis
Molecular Oncology, EarlyView.This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht +3 more
wiley +1 more source
Cahiers François Viète, 2005 The various types of observations that have confirmed the big bang models have made cosmology a science of “precision” observation. Insofar as it allows us to reconstruct the evolution of the universe, the events of which have continued to the present ...
Marc Lachièze-Rey
doaj +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source