Results 61 to 70 of about 16,073 (275)

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

Hat kárpátaljai magyar falu kecskenevei

open access: yesNévtani Értesítő, 2009
Goat names in six Hungarian settlements of the Sub-Carpathian region, Ukraine The author discusses 138 goat names of six Sub-Carpathian Hungarian settlements, examining frequency, motivation, semantics and the number of syllables.
Vince Roják
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

From toponym to appellative: the mechanism of semantic transformation of the lexeme “bedlam” in the Russian language

open access: yesНеофилология
INTRODUCTION. The lexeme “bedlam” is a striking example of a linguistic phenomenon – the transition of a proper noun into a common noun with complete determinologization and the acquisition of a stable expressive coloring. Its semantic evolution reflects
I. A. Martynenko
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Egy újabb tárgynévtípus: a 4-es metró fúrópajzsainak névadásáról

open access: yesNévtani Értesítő, 2009
A recent type of object name: naming shields of the Budapest Underground’s 4th line This paper presents a recent type of object name: it discusses the international and Hungarian practices of giving names to shields used in construction work.
Judit Raátz
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Zur Signalisierung der appellativen Textfunktion in einer Kundenzeitschrift der Apothekenbranche. Signalling the appellative function in a pharmacy sector’s customer magazine [PDF]

open access: yesKalbotyra, 2012
Customer magazines are periodically published magazines with instructive and entertaining content, which are published by companies or branches for (potential) customers and which are usually free of charge. In Germany, there are currently more than 3500
Margit Breckle
doaj  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

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