Clinical Pharmacology &Therapeutics, EarlyView.Cofetuzumab pelidotin (Cofe‐P) is an anti‐protein tyrosine kinase 7 (PTK7) antibody‐drug conjugate (ADC) being investigated for the treatment of adults with PTK7‐expressing, recurrent non‐small cell lung cancer (NSCLC). The first‐in‐human (FIH) trial demonstrated tolerability of dosages ≤ 2.8 mg/kg once every 3 weeks (Q3W) and ≤ 3.2 mg/kg Q2W ...
Carla Biesdorf +8 more
wiley +1 more source
Associations of Growth Differentiation Factor 15 in Chronic Kidney Disease. [PDF]
Kidney Int RepMcDonnell T +5 more
europepmc +1 more source
Toward Fit‐for‐Purpose Data for Drug Assessment in Non‐small Cell Lung Cancer: A Core Dataset
Clinical Pharmacology &Therapeutics, EarlyView.Considering the high unmet medical need in people with non‐small cell lung cancer (NSCLC), the drug assessment for targeted therapies often rely on small populations and single‐arm trials, challenging the evaluation by regulatory authorities, health technology assessment bodies (HTAb), and clinicians.
Geeske F. Grit +6 more
wiley +1 more source
Rise or fall? Reconciling contested directions in human gut hormone aging. [PDF]
Front Endocrinol (Lausanne)Mavrych V, Shypilova I, Bolgova O.
europepmc +1 more source
Corporate Social Responsibility and Environmental Management, EarlyView.ABSTRACT This study investigates how internal governance design supports credible ESG performance by distinguishing between Incentive and Oversight Architectures. Using 13,993 firm‐year observations of US nonfinancial firms from 2018 to 2024, we estimate fixed effects and two‐step system GMM models.
Beyza Gürel +2 more
wiley +1 more source
Cancer Cachexia Research and Drug Development: Lessons from Failures and the Promise of Immunomodulation. [PDF]
Cancers (Basel)Zhang L, Norton JA.
europepmc +1 more source
Corporate Social Responsibility and Environmental Management, EarlyView.ABSTRACT The increasing salience of climate change has intensified attention to the roe of ESG ratings in shaping firms' green innovation. We examine the link between ESG performance and green innovation, highlighting the role of participation in global innovation networks.
Miaomiao Tao +3 more
wiley +1 more source
Chrono-Nutritional Disruption as a Potential Modifiable Factor in Bipolar Disorder. [PDF]
NutrientsMazza M, Marano G.
europepmc +1 more source
Regulatory Convergence and Divergence in ESG Reporting in the Indo‐Pacific Region
Corporate Social Responsibility and Environmental Management, EarlyView.ABSTRACT Environmental, social, and governance (ESG) reporting has evolved significantly globally over the past few decades. Many countries are now signatories to international agreements such as the United Nations Framework Convention on Climate Change (UNFCCC) and the Paris Agreement, with increasing commitments to emissions reduction targets and the
Michele John +6 more
wiley +1 more source
The Effectiveness of Oral Nutrition Supplementation on Growth Indicators, Dietary Intake, Appetite, and Health Outcomes Among Underweight Preschool Children in Urban Area of Kuala Lumpur, Malaysia: A Multi-Centre Community-Based Randomised Controlled Trial. [PDF]
NutrientsAbdul Wahid AH +4 more
europepmc +1 more source