Results 171 to 180 of about 715,743 (303)

Soticlestat as an adjunctive therapy in children and young adults with Dravet syndrome

Epilepsia, EarlyView.
Overview of the phase 3 trial evaluating soticlestat as adjunctive therapy in children and young adults with Dravet syndrome. Abstract Objective This study evaluated the efficacy, safety, and tolerability of soticlestat as adjunctive therapy in children and young adults with Dravet syndrome (DS).
Joseph Sullivan, Kette Valente, Vicente Villanueva, Adam Strzelczyk, Rima Nabbout, Eiji Nakagawa, Yuehua Zhang, Marta Zolnowska, Yasir Khan, Cheng Dong, Samuel Hsiao, Sarah I. Sheikh, Philipp von Rosenstiel, Mahnaz Asgharnejad, Venkatesha Murthy   +14 more
wiley   +1 more source

A phase 3, randomized clinical trial of soticlestat as adjunctive therapy for Lennox–Gastaut syndrome

Epilepsia, EarlyView.
Soticlestat as adjunctive therapy for Lennox–Gastaut syndrome. Abstract Objective There remains a need for new treatments for Lennox–Gastaut syndrome (LGS), a developmental and epileptic encephalopathy with a heterogenous patient population that often requires polytherapy. The phase 3, randomized SKYWAY study (NCT04938427) investigated the efficacy and
Renzo Guerrini, Eric D. Marsh, Wei‐Ping Liao, Katsumi Imai, Ruzica Kravljanac, Anna Altmann, Cecil D. Hahn, Stéphane Auvin, Jimmy Schiemann, Yasir Khan, Pranab Mitra, Sarah I. Sheikh, Philipp von Rosenstiel, Mahnaz Asgharnejad, Dennis Dlugos, Venkatesha Murthy   +15 more
wiley   +1 more source

Appetite Suppressing Activity of Rumex Usambarensis Leaf and Stem Aqueous Extract in Wistar Albino Female Rats: an in vivo Experimental Study

Journal of Experimental Pharmacology
Fredrick Atwiine, Albert Mwesigwa, Derick Mwesiga, Polly Mwesigwa, Lawrence Katumba, Patrick Engeu Ogwang Department of Pharmacy, Mbarara University of Science and Technology, Mbarara, UgandaCorrespondence: Fredrick Atwiine, Mbarara University of Science
Atwiine F, Mwesigwa A, Mwesiga D, Mwesigwa P, Katumba L, Ogwang PE   +5 more
doaj  

Research Advances of Neuroregulatory Effects of Dietary Polyphenols on Obesity Complications. [PDF]

Nutrients
Han T, Wei L, Gu W, Zheng S, Du Y, Ge H, Li D, Xie Z.   +7 more
europepmc   +1 more source

Practical consensus recommendations for polytherapy involving stiripentol in Dravet syndrome: A nominal group approach

Epilepsia Open, EarlyView.
Abstract Objectives Dravet syndrome (DS) is a drug‐resistant developmental and epileptic encephalopathy, often requiring three or more antiseizure medications (ASMs). Consequently, the therapeutic landscape is highly complex, combining DS‐specific agents (stiripentol, STP; cannabidiol, CBD; fenfluramine, FFA), non‐specific ASMs, and non‐pharmacologic ...
J. Helen Cross, Rima Nabbout, Barry Gidal, Joseph Sullivan, Elaine Wirrell   +4 more
wiley   +1 more source

Genetic architecture of obesity and advances in precision pharmacotherapy: a comprehensive review. [PDF]

Acta Biochim Pol
Kavaja F, Liehr T, Temaj G.
europepmc   +1 more source

Faecal Microbiota Transplantation in Anorexia Nervosa: A Systematic Review of Methodologies, Outcomes, and Challenges With Recommendations for Future Studies

European Eating Disorders Review, EarlyView.
ABSTRACT Objective Anorexia nervosa (AN) is a severe psychiatric disorder displaying an altered gut microbiome. Faecal microbiome transplantation (FMT) has emerged as a powerful research tool and potential treatment option in AN due to the microbiome‐gut‐brain axis. Current studies are limited and reveal variable FMT protocols.
Anna C. Thelen, Nele M. Korten, Larissa Blischke, Clara Voelz, Cordian Beyer, Jochen Seitz, Stefanie Trinh   +6 more
wiley   +1 more source

Analysis of drug-induced adverse reactions affecting appetite and taste using the Japanese Adverse Drug Event Report Database. [PDF]

BMC Res Notes
Maese M, Kondo S, Sakatsume Y, Takagi M, Yokoyama Y, Iwata H, Kobayashi N, Yamaura K.   +7 more
europepmc   +1 more source

A Systematic Scoping Review of Factors Contributing to Loss of Control Eating During Pregnancy

European Eating Disorders Review, EarlyView.
ABSTRACT Objective Evidence suggests loss of control eating (LOC) during pregnancy is prevalent and linked to adverse health consequences for birthing individuals and their offspring; however, factors underlying risk for prenatal LOC remain unclear.
Riley J. Jouppi, Michele D. Levine, Rachel P. Kolko Conlon, Lydia B. Brown   +3 more
wiley   +1 more source

Glucose and Loss of Control Eating: Evidence From Naturalistic Assessment After Roux‐en‐Y Gastric Bypass

European Eating Disorders Review, EarlyView.
ABSTRACT Objective While loss of control (LOC) eating is associated with poor outcomes following metabolic and bariatric surgery (MBS), the mechanisms driving it are less understood. This study used momentary, naturalistic data to examine glucose as a biological correlate of LOC eating after Roux‐en‐Y gastric bypass (RYGB).
Gail A. Kerver, Kristine J. Steffen, Debra L. Safer, Glen Forester, David B. Sarwer, Stephen A. Wonderlich, Scott G. Engel   +6 more
wiley   +1 more source