Results 101 to 110 of about 55,178 (309)
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Public formations in municipalities as a form of public control over the local power [PDF]
Теория и практика общественного развития, 2014 The article deals with the main problems of public control over local authorities’ activities by means of Public Chambers and Public Councils. The au-thor comes to the conclusion that it's necessary to develop the clear principles of formation of these ...
Anosova Vera Vasilievna
doaj
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Ontario College Applicant Survey, 2005 [Canada]
, 2019 The Ontario College Applicant Survey was conducted by the Canada Millennium Scholarship Foundation to provide data on the decision-making process of applicants in regards to choosing a college and area of study. Colleges wanted further insight into their
Canada Millennium Scholarship Foundation
core +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Perceptions of trust and qualification in medical marijuana job applicant
, 2011 The purpose of this study was to investigate the effects of medicinal marijuana use on the perceived interpersonal trust and qualification of a job applicant.
Rachel Marjorie Elliott
core +1 more source
BMC Medical Education, 2018 Background This study examined the influence of two Situational Judgement Test (SJT) design features (response instructions and response format) on applicant perceptions.
Wendy E. De Leng +3 more
doaj +1 more source
Is It Your Foreign Name or Foreign Qualifications? An Experimental Study of Ethnic Discrimination in Hiring [PDF]
This paper contributes to the existing literature on ethnic discrimination of immigrants in hiring by addressing the central question of what employers act on in a job application.
Rooth, Dan-Olof, Carlsson, Magnus
core
Performance pay and applicant screening [PDF]
, 2015 Using German establishment data, we show that the relationship between performance pay and intensity of applicant screening depends on the nature of production.
Jirjahn, Uwe, Mohrenweiser, Jens
core