Results 131 to 140 of about 7,669,484 (262)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Microneedles enhance the efficacy of topical dental anesthesia in male subjects: a randomized controlled trial. [PDF]

Braz Oral Res
Santos SDC, Moreira NCF, Abdalla HB, Augusto GGX, Costa YM, Franz-Montan M.   +5 more
europepmc   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Comparison of the Effects of Local Heat and Massage Using the Flick Application on Pain Caused by Vitamin K Injection in Neonates. [PDF]

Pediatric Health Med Ther
Momenisoroshk J, Sadeghi T, Seyedbagheri S.   +2 more
europepmc   +1 more source

Application Development for Local Crops Business - AgrTrack

AgrTrack is a web-based POS software application designed to manage account details for small to medium-sized businesses. The primary user of the application is the administrator, who is responsible for assigning or creating roles for other ...
Waseem, Muhammad
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Development of a mobile health application to support the management of paediatric FMF. [PDF]

Rheumatology (Oxford)
Bayrak YE, Özcan H, Pir F, Şahin N, Aydın D, Sönmez HE.   +5 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Feasibility Evaluation of a Standalone Virtual Reality System for Neonatal Resuscitation Training. [PDF]

J Med Syst
Amari S, Eto M, Oyama H.
europepmc   +1 more source

Development of a Comprehensive Health and Fitness Tracker Web Application

This thesis presents the development of a comprehensive web-based health tracking application, Healthify, designed to integrate multiple health information into a single platform.
Negm, Seifeldin Mohamed Zakaria Salama Imam
core