Results 221 to 230 of about 20,531,927 (296)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Bile acid signaling in MASLD: From pathogenesis to therapeutic applications

Benedikt Simbrunner, Rafael Paternostro, Thomas Reiberger, Michael Trauner   +3 more
openalex   +1 more source

Slim Disks with Transition Regions and Applications to Microquasars and Narrow‐Line Seyfert 1 Galaxies [PDF]

, 2004
Lin‐Hong Chen, Jian‐Min Wang
openalex   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Effects of herbicide application on oil palm plantation soil bacterial diversity, function, and co-occurrence networks. [PDF]

World J Microbiol Biotechnol
Hilmi NHZ, Suhaimi NSM, Rejab NA, Rusli MH, Mohamed MS, Zawawi NZ, Mispan MS.   +6 more
europepmc   +1 more source

Synergy processing of diverse ground-based remote sensing and insitu data using GRASP algorithm: applications to radiometer, lidarand radiosonde observations

, 2020
Anton Lopatin, Оleg Dubovik, David Fuertes, Georgiy Stenchikov, Tatyana Lapyonok, Igor Veselovskii, Frank G. Wienhold, Illia Shevchenko, Qiaoyun Hu, Sagar Parajuli   +9 more
openalex   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Imputing unjustified bulk density values to soils with biochar addition biases soil carbon sequestration estimates. [PDF]

Proc Natl Acad Sci U S A
Sun D.
europepmc   +1 more source

Research Progress on the Application of Trichoderma in Plant Abiotic Stress

Meilan Zhao, Huanrui Zhao, Peng Wang, Longfei Jin, Yue Yang, Dejian Zhang   +5 more
openalex   +1 more source

Design of a Thermoelectric Generator for Waste Heat Recovery Application on a Drivable Heavy Duty Vehicle

, 2017
Arash Edvin Risseh, Hans‐Peter Nee, Olof Erlandsson, Klas Brinkfeldt, Arnaud Contet, Fabian Frobenius lng, Gerd Gaiser, Ali Saramat, Thomas Skåre, Simon Nee, Jan Dellrud   +10 more
openalex   +2 more sources