Results 41 to 50 of about 19,951,400 (295)

Structural dynamics of the plant hormone receptor ETR1 in a native‐like membrane environment

FEBS Letters, EarlyView.
The present study unveils the structural and signaling dynamics of ETR1, a key plant ethylene receptor. Using an optimized nanodisc system and solution NMR, we captured full‐length ETR1 in a native‐like membrane environment. Our findings reveal dynamic domain uncoupling and Cu(I)‐induced rigidification, providing the first evidence of metal‐triggered ...
Moritz Lemke, Nils Alexander Lakomek, Georg Groth   +2 more
wiley   +1 more source

Critical Review of Food Colloidal Delivery System for Bioactive Compounds: Physical Characterization and Application

Foods
Bioactive compounds (BACs) have attracted much attention due to their potential health benefits. However, such substances have problems such as difficulty dissolving in water, poor stability, and low intestinal absorption, leading to serious limitations ...
Bijie Wang, Jiayi LvYe, Shaoming Yang, Ying Shi, Qihe Chen   +4 more
doaj   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Structure, Functional Properties, and Applications of Foxtail Millet Prolamin: A Review

Biomolecules
Foxtail millet prolamin, one of the major protein constituents of foxtail millet, has garnered attention due to its unique amino acid composition and function. Foxtail millet prolamin exhibits specific physicochemical and functional characteristics, such
Wen Zhang, Guijun Zhang, Wenjing Liang, Jiayi Tian, Shuhao Sun, Xinping Zhang, Xinyi Lv, Peibo Guo, Ao Qu, Zijian Wu   +9 more
doaj   +1 more source

Polyurethane/Alginate Blends: A Review Account on Preparation, Properties and Applications [PDF]

علوم و تکنولوژی پلیمر
The production and consumption of synthetic polymers have faced limitations such as strict environmental laws, limited supply of raw materials, and high production costs.
Sarvenaz Nasrollahi, Abbas Mohammadi, Hengameh Honarkar   +2 more
doaj   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Using Delphi technique to build consensus in practice

International Journal of Business Science and Applied Management, 2014
This paper focuses on the use of Delphi technique in building consensus in practice. More specifically, it reviews some fuzzy issues regarding the expert's panel selection and the questionnaire design, while it provides two case examples for the ...
Zervas, E.
doaj  

Evaluating large language models: a systematic review of efficiency, applications, and future directions

Frontiers in Computer Science
Large language models, the innovative breakthrough taking the world by storm, have been applied in several fields, such as medicine, education, finance, and law.
Yasmeen Saleh, Manar Abu Talib, Qassim Nasir, Fatima Dakalbab   +3 more
doaj   +1 more source

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source