Results 111 to 120 of about 10,361,402 (288)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Moving force identification from bridge dynamic responses
, 2005 A big progress has been made for moving force identification from bridge dynamic responses in recent years. Current knowledge and the potentials on moving force identification methods are reviewed in this paper under main headings below: background of ...
Chan, Tommy H.T., Yu, Ling
core
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Flow-awared identification model of sophisticated network application
Tongxin xuebao, 2015 Traditional methods of protocol identification, which is mainly based on individual flow, lose their effective-ness as dealing with sophisticated network applications.
Luo-shi ZHANG, Da-wei WANG, Yi-bo XUE
doaj +2 more sources
UPDATE AND EVALUATION OF A CLINICAL BACTERIOLOGY MOBILE APP AS A DIGITAL LEARNING TOOL IN HEALTHCARE
Conexões: Ciência e TecnologiaDigital learning technologies have become popular among academics, teachers and professionals of various levels and areas of knowledge. Regarding the health area, m-Health can serve as support in decisions regarding diagnoses, procedures and processes ...
Bruna Ferreira Pfeiffer +1 more
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Frontiers in MicrobiologyObjectiveTo evaluate the diagnostic performance and clinical impact of microbial nanopore-targeted sequencing (NTS) technology on pathogenic microorganisms in leukemia patients.MethodsIn this retrospective observational study, we recruited 206 patients ...
Qian Yao +5 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Nanoporous smartPearls for dermal application - Identification of optimal silica types and a scalable production process as prerequisites for marketed products. [PDF]
Beilstein J Nanotechnol, 2019 Hespeler D +3 more
europepmc +1 more source