Results 101 to 110 of about 469,222 (318)

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Mapping parallel programs to heterogeneous CPU/GPU architectures using a Monte Carlo Tree Search [PDF]

open access: yes, 2013
The single core processor, which has dominated for over 30 years, is now obsolete with recent trends increasing towards parallel systems, demanding a huge shift in programming techniques and practices. Moreover, we are rapidly moving towards an age where
Brown, Christopher Mark   +11 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

An Optimized Nature-Inspired Metaheuristic Algorithm for Application Mapping in 2D-NoC. [PDF]

open access: yesSensors (Basel), 2021
Sikandar S   +5 more
europepmc   +1 more source

NavTable: an application to manage records in gvSIG [PDF]

open access: yes, 2010
[Resumen:] En la mayoría de los Sistemas de Información Geográfica de propósito general, se usan tablas con filas y columnas para acce­der a los datos alfanuméricos asociados a elementos geográficos.
Sanxiao Roca, Pablo   +3 more
core  

The Review of Land Use/Land Cover Mapping AI Methodology and Application in the Era of Remote Sensing Big Data [PDF]

open access: yes
With the increasing number of remote sensing satellites, the diversification of observation modals, and the continuous advancement of artificial intelligence algorithms, historically opportunities have been brought to the applications of earth ...
ZHANG Xinchang, SHI Qian, SUN Ying, HUANG Jianfeng, HE Da
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

An explicit KO‐degree map and applications

open access: yesJournal of Topology, 2017
The goal of this note is to study the analog in unstable ${{\mathbb A}^1}$-homotopy theory of the unit map from the motivic sphere spectrum to the Hermitian K-theory spectrum, i.e., the degree map in Hermitian K-theory. We show that "Suslin matrices", which are explicit maps from odd dimensional split smooth affine quadrics to geometric models of the ...
Asok, Aravind, Fasel, Jean
openaire   +5 more sources

Fund Finder: A case study of database-to-ontology mapping

open access: yes, 2003
The mapping between databases and ontologies is a basic problem when trying to "upgrade" deep web content to the semantic web. Our approach suggests the declarative definition of mappings as a way to achieve domain independency and reusability.
Corcho, Oscar   +2 more
core  

Statistical parametric mapping of LORETA using high density EEG and individual MRI: Application to mismatch negativities in schizophrenia

open access: yes, 2002
We describe a method for the statistical parametric mapping of low resolution electromagnetic tomography (LORETA) using high-density electroencephalography (EEG) and individual magnetic resonance images (MRI) to investigate the characteristics of the ...
박해정, 김재진
core   +1 more source

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