Results 51 to 60 of about 178,018,163 (293)
AGILE & OPEN INNOVATION FOR CROWD ENGINEERING IN NEW PRODUCT DEVELOPMENT APPLICATIONS
Annals of the Academy of Romanian Scientists Series on Engineering Sciences, 2020 The increasing complexity of designing and manufacturing of new and innovative products depends on how organizations benefit of a wide spectrum of experts. Open innovation should become more agile and “crowd” engineering is destined to organize an efficient and effective utilization of a wide set of workers, from students to researchers, start-ups and ...
Laura BOANTA +3 more
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
, 2014 Maintaining or increasing R&D efficiency and productivity is a constant challenge for R&D-driven businesses, and companies in these sectors often explore strategies seen be effective in related sectors, for example the adoption of ‘open ...
Han, Chunjia
core +1 more source
Democratising Design in Scientific Innovation: Application of an Open Value Network to Open Source Hardware Design [PDF]
, 2019 Open source hardware (OSH) development has been gaining momentum in recent years with several communities attempting to formalise its various aspects. One particularly promising area is the design of open source scientific hardware. Previous work has shown that the use of digital fabrication techniques has allowed scientists to make high-quality ...
Frangos, Maria +4 more
openaire +2 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Open Service Innovation in Health Care: What Can We Learn from Open Innovation Communities?
, 2012 The purpose of the chapter is to describe and discuss how principles from open innovation, which are primarily derived from commercial product development, could be applied to open service innovation in non-profit health care organisations.
Edenius, Mats, +5 more
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source