Results 71 to 80 of about 178,018,163 (293)

Do we teach what we research? unfolding absorptive capacity,open innovation, management innovation and clusters [PDF]

, 2012
El presente Taller de Estrategia Empresarial, es un workshop internacional organizado por la Sección de Estrategia Empresarial de la asociación ACEDE, que se celebrará en Valencia en enero de 2012.
Hervás Oliver, Jose Luis
core  

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

The openness of open innovation in ecosystems – Integrating innovation and management literature on knowledge linkages

, 2019
This is the final version. Available on open access from Elsevier via the DOI in this recordOpen innovation has rendered increased interest both in practice and research, and has expanded from dyadic transfers of ideas, to ecosystem levels.
Öberg, Christina, Öberg, Christina,, Alexander, Allen, Alexander, Allen T.,, Allen T. Alexander, Alexander, Allen,, Christina Öberg   +6 more
core   +2 more sources

Temporal-Spatial Characteristics and Ecological Risk Assessment of Heavy Metals, Sulfides and Organic Carbon in Sediment of Cage Aquaculture Area in Daqin Island

Haiyang Kaifa yu guanli
In order to understand the environmental status of the sediments in the cage culture area of Daqin Island and scientifically evaluate the ecological risk of the sediments in the area, the spatial and temporal distribution characteristics of heavy metals,
ZHAO Yuting, YU Xiaoxiao, HU Shunxin, SUN Wei, LIU Jiaqi, LIU Caili, WANG Liming, SUN Shan   +7 more
doaj  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Evaluating In Situ and OCO-3 CO₂ Observations in the Sichuan Basin Using WRF-Chem Simulations and Footprint Analysis

Remote Sensing
Revealing the spatiotemporal patterns and controlling factors of atmospheric CO2 in the Sichuan Basin (SCB) is a prerequisite for the scientific regulation of regional carbon sources and sinks.
Zhiqiang Liu, Lijuan Chen, Lixin Liu, Yuyu Zhou, Wuchao Zheng, Wan Zhou, Zhipeng Wu, Zhaofu Huang, Hao Zhu, Tianyu Zhang, Shiqi Yang   +10 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Information Management and Absorptive Capacity in Open Innovation Practices: A Conceptual Model

Journal of Information Science Theory and Practice
This study addresses information management and absorptive capacity in the context of open innovation projects—essential topics for public and private organizations.
Ana Clara Cândido, Nathalia Berger Werlang, Rogério Henrique de Araújo Júnior   +2 more
doaj   +1 more source