Results 91 to 100 of about 169,432,683 (327)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The Usefulness of Patent Stage and Sectoral Pattern in Open Innovation Licensing

Journal of Technology Management & Innovation, 2008
The relative importance to the particular industry of licensing has not been done enough empirically to pursue the route of the open innovation. That is why the industrial level research on open innovation is more complicated than that of company level ...
Jun Young Kim, Yongtae Park
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Do we teach what we research? unfolding absorptive capacity,open innovation, management innovation and clusters [PDF]

, 2012
El presente Taller de Estrategia Empresarial, es un workshop internacional organizado por la Sección de Estrategia Empresarial de la asociación ACEDE, que se celebrará en Valencia en enero de 2012.
Hervás Oliver, Jose Luis
core  

Integrating the management of socio-ethical factors into industry innovation: towards a concept of Open Innovation 2.0

, 2017
To create a sustainable future, innovations are needed that integrate socio-ethical issues. Responsible innovation provides a method for managing these issues, and tries to ensure that innovation is conducted for and with society.
T. Long, V. Blok
semanticscholar   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

An experiment in online AT open innovation

, 2011
Objective. To initiate an experiment to see if an online tool can facilitate creation of new Assistive Technology (AT) through open innovation that engages the public (primarily end users and carers), prescribers, innovators and manufacturers.
Wald, Mike, Cudd, Peter, Skuse, Sebastian, Draffan, E.A., Lee, Steve   +4 more
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

The Importance of Connecting Open Innovation to Strategy

, 2017
Companies that are experienced in open innovation integrate open innovation activities as part of their strategy. By contrast, open innovation research has not been adequately integrated into the strategy literature and vice versa.
Roijakkers, Nadine, Chesbrough , Henry, Vanhaverbeke, Wim, Roijakkers, A.H.W.M.; id_orcid, Chesbrough, Henry, Lorenz, Annika, Lorenz, A., Annika Lorenz, Chesbrough, Henry W., Wim Vanhaverbeke, Henry Chesbrough, Nadine Roijakkers   +11 more
core   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source