Results 111 to 120 of about 169,432,683 (327)

Indices of innovation: application of Data Envelopment Analysis and Malmquist Index Analysis in the assessment of R&D efficiency in R&D-critical sectors

, 2014
Maintaining or increasing R&D efficiency and productivity is a constant challenge for R&D-driven businesses, and companies in these sectors often explore strategies seen be effective in related sectors, for example the adoption of ‘open ...
Han, Chunjia
core   +1 more source

Temporal-Spatial Characteristics and Ecological Risk Assessment of Heavy Metals, Sulfides and Organic Carbon in Sediment of Cage Aquaculture Area in Daqin Island

Haiyang Kaifa yu guanli
In order to understand the environmental status of the sediments in the cage culture area of Daqin Island and scientifically evaluate the ecological risk of the sediments in the area, the spatial and temporal distribution characteristics of heavy metals,
ZHAO Yuting, YU Xiaoxiao, HU Shunxin, SUN Wei, LIU Jiaqi, LIU Caili, WANG Liming, SUN Shan   +7 more
doaj  

Evaluating In Situ and OCO-3 CO₂ Observations in the Sichuan Basin Using WRF-Chem Simulations and Footprint Analysis

Remote Sensing
Revealing the spatiotemporal patterns and controlling factors of atmospheric CO2 in the Sichuan Basin (SCB) is a prerequisite for the scientific regulation of regional carbon sources and sinks.
Zhiqiang Liu, Lijuan Chen, Lixin Liu, Yuyu Zhou, Wuchao Zheng, Wan Zhou, Zhipeng Wu, Zhaofu Huang, Hao Zhu, Tianyu Zhang, Shiqi Yang   +10 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Voluntary Contributors in Open Innovation Processes

, 2012
There is a trend among many organisations to open up their innovation processes and invite more stakeholders to contribute to it. One of these stakeholders is the voluntary contributor.
Birgitta Bergvall-Kåreborn, Bergvall-Kåreborn, Birgitta,, Ståhlbröst, Anna,, Anna Ståhlbröst   +3 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Information Management and Absorptive Capacity in Open Innovation Practices: A Conceptual Model

Journal of Information Science Theory and Practice
This study addresses information management and absorptive capacity in the context of open innovation projects—essential topics for public and private organizations.
Ana Clara Cândido, Nathalia Berger Werlang, Rogério Henrique de Araújo Júnior   +2 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Open strategies and innovation performance [PDF]

Scholarly interest in the relationship between open strategies and innovation performance has been unfailing, and in recent years has even increased. The present paper focuses on inbound open strategies and reviews various approaches (transaction costs ...
Barge-Gil, Andrés
core