Results 131 to 140 of about 169,432,683 (327)

Le déploiement des innovations sociales numériques dans les fablabs

Terminal, 2018
This articles addresses the question of digital social innovation, a recent and growing research field, through a conceptual focus on one of its application fields: open hardware in fablabs, known as places of collective making.
Maud Pélissier
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Open Source Software as Open Innovation: Experiences from the Medical Domain

, 2012
In the past decade, we have witnessed an increased interest amongst commercial and public sector organisations for Open Source Software (OSS). As any individual and organisation has the right to freely read, use, improve and redistribute the source code ...
van der Linden, Frank,, Lundell, Björn,, Björn Lundell, Frank van der Linden   +3 more
core   +1 more source

The architecture and scheme of the hybrid-augmented intelligence open innovation platform based on the virtual and real systems

智能科学与技术学报, 2019
The overall goal and problems of the construction of the hybrid-augmented intelligent open innovation platform were first put forward,and a virtual and real systems driven platform architecture scheme was proposed.Then the basic form of the platform was ...
Jun ZHANG, Lingxi LI, Yilun LIN, Tianyun ZHANG, Ke ZHANG, Peidong XU, Keyu RUAN, Dan SHEN   +7 more
doaj  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Open innovation in science

Openness and collaboration can foster breakthroughs in science and science-based innovation. As such, they can help address declining scientific productivity and tackle grand challenges of the present day.
Beck, S., Sauermann, H., Poetz, M., Grimpe, C.   +3 more
core   +1 more source

Integration of biopolymers in polyacrylic acid hydrogels: Innovations and applications in bioresources and bioproducts

Journal of Bioresources and Bioproducts
The development of sustainable biomaterials has recently attracted great interest in the fields of flexible electronics and biosensing hydrogels. Hydrogels are a class of three-dimensional spatial network structure, and their structure and shape can ...
Rui Yang, Changlei Xia, Changtong Mei, Jianzhang Li   +3 more
doaj   +1 more source