Results 121 to 130 of about 169,432,683 (327)
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Micro-Process of Open Innovation in Megaprojects Under Sense-Making Perspective
BuildingsCompared with traditional closed innovation, open innovation brings more new ideas, technologies, and resources to megaprojects, which is becoming increasingly important in the face of growing complexity and sustainability.
Fei Li, Quanle Liu, Kai Fang
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Open Innovation: Organizational Challenges of a New Paradigm of Innovation Management [PDF]
The goal of this paper is to analyze the main problems that emerge from the open innovation model. Adopting as analytical framework an organizational perspective we divide the main challenges that arise from the management of open innovation in two main ...
José López RODRÍGUEZ +1 more
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Exploration-exploitation transitions in open innovation : from preaching to practice
, 2008 This conceptual paper considers the potential for process innovation tools, such as stage-gate techniques, to ease transitions from exploration to exploitation activities in the context of Open Innovation.
Fitzgerald, Anneke (R10311) +2 more
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Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
La innovación abierta en las empresas turísticas extremeñas como herramienta de entrada en el turismo de negocios [PDF]
PASOS Revista de Turismo y Patrimonio Cultural, 2011 A key role for the development of tourism activities in some regions is the articulation of common strategies in the field of knowledge and technological innovation to harness the resources of these regions.
Rocío González Sánchez
doaj
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Building an internationally oriented open regional innovation system : a paradox perspective [PDF]
, 2019 An open regional innovation system is often characterised by the firms' adoption of an open innovation strategy, which is closely linked to absorptive capacity. This study explores the effects of the firms' absorptive capacity on open regional innovation
Kuusisto, Arja, Liang, Liting S.
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