Results 81 to 90 of about 178,018,163 (293)
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
Open strategies and innovation performance [PDF]
Scholarly interest in the relationship between open strategies and innovation performance has been unfailing, and in recent years has even increased. The present paper focuses on inbound open strategies and reviews various approaches (transaction costs ...
Barge-Gil, Andrés
core
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
Exploration-exploitation transitions in open innovation : from preaching to practice
, 2008 This conceptual paper considers the potential for process innovation tools, such as stage-gate techniques, to ease transitions from exploration to exploitation activities in the context of Open Innovation.
Fitzgerald, Anneke (R10311) +2 more
core
Openness and collaboration can foster breakthroughs in science and science-based innovation. As such, they can help address declining scientific productivity and tackle grand challenges of the present day.
Beck, S. +3 more
core +1 more source
Open Source Software as Open Innovation: Experiences from the Medical Domain
, 2012 In the past decade, we have witnessed an increased interest amongst commercial and public sector organisations for Open Source Software (OSS). As any individual and organisation has the right to freely read, use, improve and redistribute the source code ...
van der Linden, Frank, +3 more
core +1 more source
The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection
Molecular Oncology, EarlyView.Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński +12 more
wiley +1 more source
Open Innovation: Organizational Challenges of a New Paradigm of Innovation Management [PDF]
The goal of this paper is to analyze the main problems that emerge from the open innovation model. Adopting as analytical framework an organizational perspective we divide the main challenges that arise from the management of open innovation in two main ...
José López RODRÍGUEZ +1 more
core
Voluntary Contributors in Open Innovation Processes
, 2012 There is a trend among many organisations to open up their innovation processes and invite more stakeholders to contribute to it. One of these stakeholders is the voluntary contributor.
Birgitta Bergvall-Kåreborn +3 more
core +1 more source
Micro-Process of Open Innovation in Megaprojects Under Sense-Making Perspective
BuildingsCompared with traditional closed innovation, open innovation brings more new ideas, technologies, and resources to megaprojects, which is becoming increasingly important in the face of growing complexity and sustainability.
Fei Li, Quanle Liu, Kai Fang
doaj +1 more source