Results 81 to 90 of about 169,432,683 (327)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

AGILE & OPEN INNOVATION FOR CROWD ENGINEERING IN NEW PRODUCT DEVELOPMENT APPLICATIONS

Annals of the Academy of Romanian Scientists Series on Engineering Sciences, 2020
The increasing complexity of designing and manufacturing of new and innovative products depends on how organizations benefit of a wide spectrum of experts. Open innovation should become more agile and “crowd” engineering is destined to organize an efficient and effective utilization of a wide set of workers, from students to researchers, start-ups and ...
Laura BOANTA, Alexandru MARIN, Miron ZAPCIU, Liliana MARINESCU   +3 more
openaire   +2 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Implementing open licensing in government open data initiatives: a review of Australian government practice [PDF]

, 2013
This paper finds that Australian Government agencies are embracing open access and a proactive disclosure culture, and that open licensing under Creative Commons licences is increasingly prevalent, but that shortcomings need to be addressed.
Anne Fitzgerald, Hooper, Neale, John S. Cook, Neale Hooper, Fitzgerald, Anne, Cook, John S.   +5 more
core   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Open Innovation and Startups

This book comprehensively discusses the cooperation of corporations with startups in the context of accelerator programs. It focuses on recognizing how open innovation can catalyze startups’ development and success, and benefit corporations through ...
Bańka, Michał
core   +1 more source

Factors Affecting Outbound Open Innovation Performance in Bio-Pharmaceutical Industry-Focus on Out-Licensing Deals

, 2021
Due to the high risk in development process, the bio-pharmaceutical industry has transformed itself into an open innovation framework in order to overcome economic risk.
Eungdo Kim, Ingyu Lee, Hongbum Kim, Kwangsoo Shin   +3 more
semanticscholar   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Activating The Partnership between University and Socio-Economic Environment Through Open Innovation (A Field Study)

المجلة العربية لضمان جودة التعليم الجامعي, 2016
The study aims to examine the status of the relationship between the Algerian University and the socio-economic environment and the ways to activate it.
Zakia Megri, Assia Chenna, Imene Fourar
doaj   +1 more source