Results 121 to 130 of about 1,180,981 (295)
Advanced Science, EarlyView.Dominant antimicrobial resistance reservoirs in Klebsiella pneumoniae vary across eco‐geographic settings rather than following a universal pattern. Integrated One Health and global genomic analyses show that lineage structure, integron load, and cross‐niche connectivity shape whether AMR burden accumulates primarily in human or nonhuman compartments ...
Hui Lin +12 more
wiley +1 more source
Development and/or modeling (like Web or Android) application
, 2019 Application development is a process of design, developing, deploying and operating the software application or software programs to perform different tasks for different business majors.
Onat, Mert
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Investigating the relationship between software process improvement, situational change, and business success in software SMEs [PDF]
, 2012 While we have learned a great deal from Software Process Improvement (SPI) research to date, no earlier study has been designed from the outset to examine the relationship between SPI and business success in software development small- to- medium- sized ...
Clarke, Paul
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Advanced Science, EarlyView.This study identifies the mechanosensor PIEZO1 as a key factor in promoting acute myeloid leukemia progression and uncovers a ferroptosis defense system mediated by PIEZO1‐HIF1A‐SLC7A11 axis that is essential for leukemia stem cell maintenance. This ferroptotic defense system may represent a unique vulnerability for leukemia stem cells, providing a ...
Tiantian Zhang +10 more
wiley +1 more source
Applying Scrum and Organizational Patterns to Multi-site Software Development
, 2007 This paper describes a pattern language for managing multi-site software projects which aims at minimizing the main problems present on the multi-site software development context. The practices and patterns of the proposed language were first identified
Cordeiro, Lucas +2 more
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PDIA6–SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression
Advanced Science, EarlyView.Protein disulfide isomerase A6 (PDIA6) is identified as an oncogenic driver in gastric cancer. PDIA6 directly binds and stabilizes SCD1 by limiting its ubiquitin–proteasome‐mediated degradation, thereby sustaining monounsaturated fatty acid (MUFA)‐enriched lipid homeostasis and lipid metabolic reprogramming.
Zhen Tian +13 more
wiley +1 more source
Advanced Science, EarlyView.In response to hypertrophic stimuli, increased c‑JUN phosphorylation upregulates RNF115, leading to SPTBN1 ubiquitination and degradation. which promotes F‑actin depolymerization and YAP activation, driving cardiac hypertrophy. The RNF115 inhibitor DTD effectively suppresses SPTBN1 ubiquitination and cardiac hypertrophy.
Yan Zu +12 more
wiley +1 more source
Modelo multicritério de apoio à decisão construtivista no processo de avaliação da aderência dos requisitos de um software [PDF]
, 2014 Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia de Produção, Florianópolis, 2014.Os atuais desafios das companhias de desenvolvimento de software deERP envolvem o constante ...
Rocha, Silvano
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Advanced Science, EarlyView.ANXA2+ sEVs promote cisplatin resistance in ATC by stabilizing the SRC/LDHA interaction, increasing LDHA phosphorylation and activity, and lactate production. Elevated lactate levels promote KAT5‐mediated lactylation of XRCC5 at lysine 265, enhancing its binding to XRCC6.
Shanshan Su +4 more
wiley +1 more source
A distributed solution to software reuse [PDF]
, 2008 Reuse can be applied to all stages of the software lifecycle to enhance quality and to shorten time of completion for a project. During the phases of design and implementation are some examples of where reuse can be applied, but one frequent obstruction ...
McGuigan, James F.
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