Results 121 to 130 of about 23,571 (213)

Challenges and Opportunities for Theory-Grounded Data Visualization in Extended Reality. [PDF]

IEEE Comput Graph Appl
Bueckle A, Hutter CVR, Raidou RG, Bryan C, Mindek P, Kaufmann H, Elmqvist N, Menche J, Borner K, Rhyne TM.   +9 more
europepmc   +1 more source

ERα–PADI4–CXCL8 Axis Drives MDSC‐Mediated Immune Evasion in Anaplastic Thyroid Carcinoma

Advanced Science, EarlyView.
MAPK‐driven ligand‐independent ERα activation drives PADI4 transcription and translation. This enzyme then modifies CXCL8 chemokines through citrullination, generating a potent chemoattractant gradient specifically for myeloid‐derived suppressor cells.
Dongdong Zhang, Ying Cai, Junbin Zhang, Jianyong Zhang, Ran Jing, Ming Cai   +5 more
wiley   +1 more source

Immersive Technologies in Sport Spectatorship: A Scoping Review of Psychological Responses and Behavioral Intentions. [PDF]

Behav Sci (Basel)
Xiong Y, Kim D, Kim K.
europepmc   +1 more source

SPRED2 Negatively Regulates CD8+ T Cell‐Mediated Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
Sprouty‑related EVH1 domain containing 2 (SPRED2) restrains Ras/Raf/ERK signaling in CD8+ T cells. Host SPRED2 deficiency enhances T‐cell survival, cytotoxicity, and memory‐like phenotypes, reducing primary tumor growth and endpoint lung metastatic burden in breast cancer models.
Miao Tian, Teizo Yoshimura, Kun Zhao, Chunning Li, Tong Gao, Ziyi Wang, Masayoshi Fujisawa, Toshiaki Ohara, Akihiro Matsukawa   +8 more
wiley   +1 more source

Hyperedge approximation for stochastic processes on higher-order networks. [PDF]

Proc Natl Acad Sci U S A
Sheng A, McAvoy A, Tian Y, Zhang S, Fontan A, Plotkin JB.   +5 more
europepmc   +1 more source

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

Integrating Artificial Intelligence with Gamification in Medical Education: A Pedagogically Grounded Framework and Critical Review. [PDF]

Adv Med Educ Pract
Bharatha A, Ojeh N, Campbell MH, Krishnamurthy K, Sangishetti VP, Bhuvanagiri L, Gupta S, Rahman S, Reddy S, Majumder MAA.   +9 more
europepmc   +1 more source

Degrading GPX4 via Biomimetic Nanoparticle‐Mediated In Situ Synthesis of Deep‐Learning‐Designed Binder‐Degron Chimeras for Prostate Cancer Therapy

Advanced Science, EarlyView.
A deep‐learning‐designed binder is fused to a combinatorial degron to create a binder‐degron chimera (bdC) that recruits the CUL2‐RING ubiquitin ligase complex. Encapsulation in a prostate‐cancer‐targeted, CD47‐camouflaged nanocarrier enables tumor‐specific in situ bdC expression, triggering GPX4 degradation and ferroptosis, thereby establishing a ...
Si‐Han Zhang, Ye An, Na Zeng, Mei‐Cheng Liu, Jian‐Xuan Sun, Xi Gong, Jin‐Zhou Xu, Shao‐Gang Wang, Qi‐Dong Xia   +8 more
wiley   +1 more source

The scientific game : Strategic Behavior and Incentives in Science. [PDF]

EMBO Rep
Bornmann L, Osório A.
europepmc   +1 more source

Gamification Elements in Physical Activity Interventions: Scoping Review and Taxonomy Based on the Octalysis Framework. [PDF]

JMIR Serious Games
Li S, Qiao L, Wang RN, Pei R, Ma HM, Piao MH.   +5 more
europepmc   +1 more source