Results 91 to 100 of about 166,587,123 (294)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Applications of graph theory to matrix theory [PDF]

open access: yesProceedings of the American Mathematical Society, 1975
Let A 1 ,
openaire   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Multilayer Drawings of Clustered Graphs

open access: yes, 2014
The cluster adjacency graph of a flat clustered graph C(G, T ) is the graph A whose vertices are the clusters in T and whose edges connect clusters containing vertices that are adjacent in G.
Fabrizio Frati, FRATI, FABRIZIO
core   +1 more source

“Applications of Graph Theory”

open access: yesInternational Journal of Latest Technology in Engineering Management & Applied Science
Abstract: Graph theory is a fundamental area of mathematics with diverse applications across multiple fields. It provides a structural framework for solving complex problems by representing objects and their relationships as graphs. In computer science, graph theory is used in networking, algorithms, and artificial intelligence. It plays a crucial role
null Rohini Gore   +3 more
openaire   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Smarandache-Zagreb Index on Three Graph Operators [PDF]

open access: yes, 2010
Many researchers have studied several operators on a connected graph in which one make an attempt on subdivision of its edges. In this paper, we show how the Zagreb indices, a particular case of Smarandache-Zagreb index of a graph changes with these ...
Ranjini, P.S., Lokesha, V.
core   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

A Brief Overview of Applications of Tree-Width and Other Graph Width Parameters

open access: yesApplied Mathematics on Science and Engineering
Graph theory, a fundamental branch of mathematics, centers on the study of networks composed of vertices (nodes) and edges, examining their paths, structures, and properties.
Takaaki Fujita
doaj   +1 more source

Topological Descriptor of 2-Dimensional Silicon Carbons and Their Applications

open access: yesOpen Chemistry, 2019
The Chemical graph theory is extensively used in finding the atomic supplementary properties of different chemical stuructures. Many results of graph theory are commonly used in molecular structures and in general in Chemisty.
Nadeem Muhammad   +3 more
doaj   +1 more source

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