Results 51 to 60 of about 40,939 (252)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

Saigo fractional q-integral involving the generalized q-hypergeometric series and a general class of q-polynomials

open access: yesArab Journal of Basic and Applied Sciences, 2023
The fractional q-calculus has attracted the interest of a large number of academics over the last four decades or so, due mainly to a wide range of applications that cover natural sciences to social sciences.
Biniyam Shimelis, D. L. Suthar
doaj   +1 more source

An application of hypergeometric functions to a problem in function theory [PDF]

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 1981
In some recent work in univalent function theory, Aharonov, Friedland, and Brannan studied the series . Brannan posed the problem of determining . Brannan showed that if β ≥ α ≥ 0, and α + β ≥ 2, then (α, β) ∈ S. He also proved that (α, 1) ∈ S for α ≥ 1.
openaire   +2 more sources

Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron   +5 more
wiley   +1 more source

Counting With Irrational Tiles [PDF]

open access: yes, 2014
We introduce and study the number of tilings of unit height rectangles with irrational tiles. We prove that the class of sequences of these numbers coincides with the class of diagonals of N-rational generating functions and a class of certain binomial ...
Garrabrant, Scott, Pak, Igor
core   +1 more source

Classification of integrable two-component Hamiltonian systems of hydrodynamic type in 2+1 dimensions

open access: yes, 2010
Hamiltonian systems of hydrodynamic type occur in a wide range of applications including fluid dynamics, the Whitham averaging procedure and the theory of Frobenius manifolds. In 1+1 dimensions, the requirement of the integrability of such systems by the
A. V. Odesskii   +10 more
core   +1 more source

Biomimetic Copper‐Doped Nano‐Aluminum Adjuvant Potentiates Therapy in Chemoresistant Acute Myeloid Leukemia

open access: yesAdvanced Healthcare Materials, EarlyView.
We developed a novel copper‐doped aluminum nano‐adjuvant (CuNA) to overcome cytarabine resistance in acute myeloid leukemia (AML). CuNA effectively sensitizes drug‐resistant AML cells to cytarabine by inducing mitochondrial dysfunction and inhibiting HMGCR/GPX4 to amplify ferroptosis.
Chao He   +10 more
wiley   +1 more source

On Analytical Continuation of the Horn’s Hypergeometric Functions H3 and Their Ratios

open access: yesAxioms
This paper considers the Horn’s hypergeometric function H3, which is closely related to other hypergeometric functions and has various mathematical or physical applications.
Roman Dmytryshyn   +2 more
doaj   +1 more source

Integration of Hypergeometric Supertrigonometric Functions Using Generalized Hypergeometric Functions and its Applications

open access: yesJournal of Institute of Science and Technology
This study explores the integration of hypergeometric supertrigonometric functions, with a particular focus on hypergeometric supersine and hypergeometric supercosine functions, by leveraging the properties and relationships of generalized hypergeometric functions.
Ganesh Bahadur Basnet   +2 more
openaire   +1 more source

A 3D Astrocyte Microenvironment Model Enables Rapid Ca2+‐Resolved Analysis and Therapeutic Modulation of Oxidative Neuroinflammation

open access: yesAdvanced Healthcare Materials, EarlyView.
This work presents ARC‐3D, a soft 3D model that recreates how brain support cells, called astrocytes, react to oxidative stress. The system visualizes rapid calcium changes and inflammatory signals, and shows how the drug KDS12025 can protect cells from damage. ARC‐3D offers a simple, reliable way to study early drivers of brain inflammation.
Ju‐Kang Kim   +6 more
wiley   +1 more source

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