Results 61 to 70 of about 6,204 (225)

SDPR–STK38 axis controls the proliferation–differentiation balance in alveolar type II cells

Animal Models and Experimental Medicine, EarlyView.
The present study identifies SDPR as a pivotal regulator orchestrating the balance between proliferation and differentiation in alveolar type II (AT2) cells. In SDPR+/+ cells, SDPR binds to and inhibits STK38 activity, thereby sustaining GSK‐3β signaling functionality to promote cyclin D1 degradation and maintain cell cycle homeostasis.
Jie Wang, Xuepei Lei, Yiying Huang, Jiaming Tang, Guiying Shi, Hang Li, Lin Bai   +6 more
wiley   +1 more source

Single‐cell atlas of neuroglial dynamics in SNCA‐A53T Parkinson's disease mouse model

Animal Models and Experimental Medicine, EarlyView.
We performed single‐cell RNA sequencing of midbrain and striatal tissues from SNCA‐A53T Parkinson's disease (PD) mice, revealing glia‐enriched PD‐risk gene signatures and disease‐specific subpopulations. Transcriptional dysregulation of key TFs (e.g., Rorb, Foxc1) and enhanced neuroinflammatory signaling (SEMA, CCL, MIF) were identified.
Binqing Qin, Zichu Fu, Xuanxuan Zou, Senmao Chai, Jingjing Weng, Puqing Wang, Xiaodong Sun, Ming Sang   +7 more
wiley   +1 more source

Four Families of Summation Formulas for ₄F₃(1) with Application

Axioms
A collection of functions organized according to their indexing based on non-negative integers is grouped by the common factor of fixed integer N. This grouping results in a summation of N series, each consisting of functions partitioned according to ...
Belakavadi Radhakrishna Srivatsa Kumar, Arjun K. Rathie, Junesang Choi   +2 more
doaj   +1 more source

Recent Developments of Hilbert-Type Discrete and Integral Inequalities with Applications

International Journal of Mathematics and Mathematical Sciences, 2012
This paper deals with recent developments of Hilbert-type discrete and integral inequalities by introducing kernels, weight functions, and multiparameters.
Lokenath Debnath, Bicheng Yang
doaj   +1 more source

Integration of Hypergeometric Supertrigonometric Functions Using Generalized Hypergeometric Functions and its Applications

Journal of Institute of Science and Technology
This study explores the integration of hypergeometric supertrigonometric functions, with a particular focus on hypergeometric supersine and hypergeometric supercosine functions, by leveraging the properties and relationships of generalized hypergeometric functions.
Ganesh Bahadur Basnet, Narayan Prasad Pahari, Resham Prasad Paudel   +2 more
openaire   +1 more source

Comparative Transcriptional Profiling of Key Macrophage and Fibroblast Subpopulations in Rheumatoid Arthritis–Associated Lung Disease

Arthritis &Rheumatology, EarlyView.
Objective Rheumatoid arthritis (RA) often involves extra‐articular complications, including interstitial lung disease (ILD) and/or pulmonary nodules. Transcriptomic profiling of lung tissue provides the opportunity to directly assess cell‐specific gene expression and corresponding pathway activation in different types of rheumatoid lung disease ...
Tracy Tabib, Ogechukwu Ezenwa, Joshua Sciurba, Eleanor B. Valenzi, John Sembrat, Brittany Cody, Jishnu Das, Robert Lafyatis, Dana P. Ascherman   +8 more
wiley   +1 more source

Triggered Calcium Lightning Programs Cochlear Development

Exploration, EarlyView.
Summary: Before the onset of hearing, the developing inner ear generates spontaneous calcium signals that are thought to guide maturation. In this study, we discovered a rapid and widespread calcium flash—dubbed “Ca2+ lightning”—originating from supporting cells beneath the sensory hair cells, which triggers coordinated calcium waves across the entire ...
Qiang Ma, Hai‐Peng Wang, Yu‐Meng Jiang, Ke Lai, Ming‐Xian Li, Zhen Zhang, Li‐Na Gong, Jing‐Wei Lai, Kai‐Ming Su, Lu‐Yang Wang, Hui Wang, Shan‐Kai Yin, Hao He, Hai‐Bo Shi   +13 more
wiley   +1 more source

DNA Methylation and Transcriptomic Profiles of Wilms Tumour Reveal New Deregulated Genes and Epigenetic Processes Relevant for Tumour Stratification and Management

International Journal of Cancer, EarlyView.
ABSTRACT Wilms Tumour (WT), the most common kidney cancer in children, presents features of altered kidney development and frequently exhibits molecular alterations at the 11p15.5 imprinted locus, affecting the IGF2 and H19 genes, which contribute to tumour growth and predisposition.
Abu Saadat, Francesco Cecere, Federica Rossetti, Laura Pignata, Emilia D'Angelo, Carlo Giaccari, Gaetano Verde, Paola Quarello, Franca Fagioli, Josep Roma, Manel Esteller, Enrique de Álava, Flavia Cerrato, Andrea Riccio, Angela Sparago   +14 more
wiley   +1 more source

Transformation and Summation Formulas for Exton's Functions K11, K14 And K15

مجلّة جامعة عدن للعلوم الأساسيّة والتّطبيقيّة, 2020
The aim of the present paper is to establish some transformation formulas for Exton's quadruple hypergeometric functions K11, K14 and K15. Several summation formulas for K11, K14 and K15 are also derived as an applications of our main results with the ...
Ahmed Ali Atash, Hussein Saleh Bellehaj
doaj  

Hadamard k-fractional inequalities of Fejér type for GA-s-convex mappings and applications

Journal of Inequalities and Applications, 2019
The main aim of this paper is to establish some Fejér-type inequalities involving hypergeometric functions in terms of GA-s-convexity. For this purpose, we construct a Hadamard k-fractional identity related to geometrically symmetric mappings.
Hui Lei, Gou Hu, Zhi-Jie Cao, Ting-Song Du   +3 more
doaj   +1 more source