Results 61 to 70 of about 782,440 (256)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Porphyrin-based electrospun nanomaterials for life science applications

BBA Advances
Porphyrins are renowned for their utility in photocatalysis, electronics, sensors, solar cell dyes, and environmental remediation. However, their potential in life sciences applications remains underexplored, particularly in the context of encapsulation ...
Ana C. Mendes, Nuno M.M. Moura, M. Amparo F․ Faustino, M. Graça P.M.S. Neves, Ioannis S. Chronakis   +4 more
doaj   +1 more source

Applications and Challenges of Artificial Intelligence in Life Sciences [PDF]

SHS Web of Conferences
With the continuous development of science and technology, exploration in the field of life sciences has become increasingly profound, encompassing the understanding of human beings themselves and the exploration of disease etiology and treatment methods.
Liu Tianyao, Li Wenbo
doaj   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Harmonizing Innovations: An In-Depth Comparative Review on the Formulation, Applications, and Future Perspectives of Aerogels and Hydrogels in Pharmaceutical Sciences

Gels
Gels, specifically hydrogels and aerogels, have emerged as versatile materials with profound implications in pharmaceutical sciences. This comprehensive review looks into detail at hydrogels and aerogels, providing a general introduction to gels as a ...
Nour Alhuda Alaghawani, Hala Alkhatib, Layla Elmancy, Anis Daou   +3 more
doaj   +1 more source

Mixed methods grant applications in the health sciences: An analysis of reviewer comments.

PLoS ONE, 2019
Our aim was to understand how reviewers appraise mixed methods research by analyzing reviewer comments for grant applications submitted primarily to the National Institutes of Health.
Timothy C Guetterman, Rae V Sakakibara, Vicki L Plano Clark, Mark Luborsky, Sarah M Murray, Felipe González Castro, John W Creswell, Charles Deutsch, Joseph J Gallo   +8 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Implementacja algorytmów ewolucyjnych w gospodarce opartej na wiedzy

Przedsiębiorczość - Edukacja, 2008
The paper elaborates on the conception of the action and the typology of evolutionaryalgorithms as the broadly used research and optimization technique based on Darwinian Theoryof evolution and modern natural genetics.
Marek Sieja, Krzysztof Wach
doaj