Results 101 to 110 of about 12,911,308 (318)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Agricultural and Applied Economics: What is This?
, 2012 The scientific domain of «agricultural and applied economics» is an open issue. In this paper, we analyse the JEL codes of the articles published in seven major agricultural economics journals in the period 2000-11, in order to define which disciplines ...
Sckokai, Paolo, Paolo Sckokai
core +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Department of Applied Mathematics and Statistics Newsletter, November 10, 2025 [PDF]
Newsletter of the Department of Applied Mathematics and Statistics at Colorado School of ...
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Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Summary of Research 2001, Department of Applied Mathematics [PDF]
, 2001 The views expressed in this report are those of the authors and do not reflect the official policy or position of the Department of Defense or U.S. Government.This report contains project summaries of the research projects in the Department of Applied ...
Faculty of the Naval Postgraduate School, Department of Applied Mathematics
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Retracted: Effective Graph Mining for Educational Data Mining and Interest Recommendation
Applied Bionics and Biomechanics, 2023 Applied Bionics and Biomechanics
doaj +1 more source