Results 81 to 90 of about 5,130,231 (273)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

A decision model applied to alcohol effects on driver signal light behavior [PDF]

, 1978
A decision model including perceptual noise or inconsistency is developed from expected value theory to explain driver stop and go decisions at signaled intersections.
Allen, R. W., Schwartz, S. H.
core   +1 more source

Simulation of static critical phenomena in non-ideal fluids with the Lattice Boltzmann method

, 2012
A fluctuating non-ideal fluid at its critical point is simulated with the Lattice Boltzmann method. It is demonstrated that the method, employing a Ginzburg-Landau free energy functional, correctly reproduces the static critical behavior associated with ...
A. B. Zamolodchikov, A. Onuki, D. d’Humieres, D. J. Amit, F. Varnik, G. Parisi, J. G. Brankov, J. J. Binney, J. L. Cardy, J. M. Yeomans, J. V. Sengers, J. Zinn-Justin, K. Binder, L. D. Landau, M. Gross, M. Krech, N. Goldenfeld, P. Kopietz, P. M. Chaikin, S. Succi, S.-K. Ma, V. L. Pokrovskii, V. Privman   +22 more
core   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Oral Hygiene in Children with Autism: Teaching Self-Toothbrushing via Behavioural Intervention Including Parents

Children
Background/Objectives: Children on the autism spectrum experience more oral hygiene issues than peers, and tooth-brushing behavior seems particularly challenging for them since it includes diverse skills and collaboration.
Marco Esposito, Carlotta Piersanti, Roberta Fadda, Marco Boitani, Monica Mazza, Giuseppina Marrocco   +5 more
doaj   +1 more source

A Theoretical Analysis of Cooperative Behavior in Multi-Agent Q-learning [PDF]

A number of experimental studies have investigated whether cooperative behavior may emerge in multi-agent Q-learning. In some studies cooperative behavior did emerge, in others it did not. This report provides a theoretical analysis of this issue.
Kaymak, U., Waltman, L.R.
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Phase transitions in the one-dimensional frustrated quantum XY model and Josephson-junction ladders

, 1994
A one-dimensional quantum version of the frustrated XY (planar rotor) model is considered which can be physically realized as a ladder of Josephson-junctions at half a flux quantum per plaquette.
Bradley R. M., Cardy J. L., Enzo Granato, Gabay M., Geerligs L. J., Granato E., Granato E., Granato E., Granato E., Granato E., Granato E., Granato E., Granato E., Granato E., Halsey T. C., Kardar M., Lee J., Lee J., Ramirez-Santiago G., Teitel S., Thijssen J. M., van der Zant H. S. J.   +21 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source