Results 31 to 40 of about 1,400,328 (262)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Decision discovery using clinical decision support system decision log data for supporting the nurse decision-making process

BMC Medical Informatics and Decision Making
Background Decision-making in healthcare is increasingly complex; notably in hospital environments where the information density is high, e.g., emergency departments, oncology departments, and psychiatry departments. This study aims to discover decisions
Matthijs Berkhout, Koen Smit, Johan Versendaal   +2 more
doaj   +1 more source

Profesjonsetiske utfordringer

Etikk i Praksis: Nordic Journal of Applied Ethics, 2011
Dette nummeret av Etikk i praksis er i utgangspunktet ikke et temanummer. Profesjonsetiske utfordringer synes likevel å utgjøre et gjennomgangstema i de fleste av artiklene som utgis i dette nummeret.
Berge Solberg, Rune Nydal, Bjørn Myskja
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

La gouvernance des projets d’architecture : une typologie de la multi-organisation temporaire [PDF]

Les Ateliers de l’Ethique, 2010
Traditional approaches to ethics in architecture have focused on three characteristics of the object: durability, convenience and beauty (firmitas, utilitas and venustas).
Gonzalo Lizarralde, Manel Djemel
doaj  

Temanummer om styring av naturressurser

Etikk i Praksis: Nordic Journal of Applied Ethics, 2014
Dette nummeret av Etikk i praksis – Nordic Journal of Applied Ethics er et temanummer om styring av naturressurser. Den tematiske delen inneholder tre artikler, mens den åpne delen har to artikler som drøfter svært dagsaktuelle tema.
May Thorseth, Siri Granum Carson
doaj   +1 more source

Ethical Challenges of Educators in Cyberspace and Ways out of it [PDF]

International Multidisciplinary Journal of Pure Life, 2019
Education is one of the human affairs that has been important because of its prominent role in all matters of human life; So that it has always been considered by experts and each of them has emphasized it with a statement.
Behnam Reihani (Iran)
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Savoirs experts et idiome quotidien. Biens et vertus de la conception participative des velos de quartiers à Trois-Rivières [PDF]

Les Ateliers de l’Ethique, 2010
This paper analyzes the development of a public bike system initiated by a civic organization that treats participation as a core principle. The analysis shows that the satisfaction of the goals pursued through the adoption of participative principles ...
Philippe Gauthier
doaj