Results 51 to 60 of about 1,400,328 (262)
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Strategies for Boosting Trustworthiness from Individual and Social Aspect [PDF]
Islām va ̒ulūm-i ijtimā̒īThe present paper views the strategies for boosting trustworthiness from individual and social perspectives. In Islamic ethics, trustworthiness is regarded as a moral virtue.
Hosseinali Arabi
doaj
Anthropology and/as an applied ethics
Etnoantropološki Problemi, 2008 In the context of the upcoming reactivation of the Serbian Ethnology and Anthropology society and the normalization of the work of professional associations, as well as their occasional adoption of their ethic codes in Serbia, we are analyzing the ethic
Bojan Tepavčević, Miloš Milenković
doaj +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
A University Applied Ethics Center: The Markkula Center for Applied Ethics at Santa Clara University
Journal of Moral Theology, 2020 The Markkula Center for Applied Ethics at Santa Clara University is a multi-program, university-based, applied ethics center. Since its founding in 1986, the Center has played a major role in promoting ethical discussion at the university, as well as in ...
Brian P. Green +6 more
doaj
How to derive ethically appropriate recommendations for action? A methodology for applied ethics. [PDF]
Med Health Care Philos, 2023 Schleidgen S +5 more
europepmc +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
La dimension institutionnelle du développement durable [PDF]
Les Ateliers de l’Ethique, 2006 The United Nations Conference on Environment and Development (UNCED) held in Rio de Janeiro in June 1992 was, without a doubt, a landmark event of contemporary multilateral cooperation.
Ahmed Djoghlaf
doaj