Results 71 to 80 of about 2,779,436 (352)

Corporate ethical identity as determinant of firm performance : a test of the mediating role of stakeholder satisfaction [PDF]

, 2005
In this article, we empirically assess the impact of the Corporate Ethical Identity (CEI) on the firm's financial performance. Drawing on formulation of both normative and instrumental stakeholder theory, we argue that firms with a strong ethical ...
Berrone, Pascual Alberto, Surroca Aguilar, Jorge, Tribo Gine, José Antonio   +2 more
core   +1 more source

Teaching ethics:intersectionality, care failure and moral courage [PDF]

, 2018
Highlights• Provides a critical discussion of ethics teaching arguing that it must recognise begin to recognise frameworks from outside the Anglo-European tradition.• Drawing on examples of care failure, racism and sexism, argues that there is evidence ...
DeSouza, R., Ion, R., Kerin, T.
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Strategies for Boosting Trustworthiness from Individual and Social Aspect [PDF]

Islām va ̒ulūm-i ijtimā̒ī
The present paper views the strategies for boosting trustworthiness from individual and social perspectives. In Islamic ethics, trustworthiness is regarded as a moral virtue.
Hosseinali Arabi
doaj  

Anthropology and/as an applied ethics

Etnoantropološki Problemi, 2008
In the context of the upcoming reactivation of the Serbian Ethnology and Anthropology society and the normalization of the work of professional associations, as well as their occasional adoption of their ethic codes in Serbia, we are analyzing the ethic
Bojan Tepavčević, Miloš Milenković
doaj   +1 more source

Judicial Interpretation of State Ethics Rules Under the McDade Amendment: Do Federal or State Courts Get the Last Word? [PDF]

, 2015
The McDade Amendment ( the Act ) is a federal law that requires federal prosecutors to abide by the state ethics rules of the jurisdiction in which they practice. The Act does not say, however, whether federal or state courts are definitive when it comes
Costello, Hopi
core   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

A University Applied Ethics Center: The Markkula Center for Applied Ethics at Santa Clara University

Journal of Moral Theology, 2020
The Markkula Center for Applied Ethics at Santa Clara University is a multi-program, university-based, applied ethics center. Since its founding in 1986, the Center has played a major role in promoting ethical discussion at the university, as well as in ...
Brian P. Green, Irina Raicu, Margaret R. McLean, Ann Skeet, Kirk O. Hanson, David DeCosse, Don Heider   +6 more
doaj