Results 121 to 130 of about 14,103,706 (328)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
iScienceSummary: We propose a time-domain adjoint optimization method for achromatic metalens design, achieving high efficiency and near-uniform spectral response.
Mingyu Park +2 more
doaj +1 more source
Matching optics for Gaussian beams [PDF]
, 1991 A system of matching optics for Gaussian beams is described. The matching optics system is positioned between a light beam emitter (such as a laser) and the input optics of a second optics system whereby the output from the light beam emitter is ...
Gunter, William D.
core
Micro scanning mirrors and enabling technology for applied optics
, 2022 Paper AIT4B.1Micro scanning mirrors play an important role in various optical applications for highly miniaturized, reliable and cost efficient scanning systems like compact laser projection displays, endoscopic and medical imaging systems or LIDAR 3D ...
Sandner, Thilo
core +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Nonlinear Optics and Applications [PDF]
, 2007 Nonlinear optics is the result of laser beam interaction with materials and started with the advent of lasers in the early 1960s. The field is growing daily and plays a major role in emerging photonic technology.
Frazier, Donald O. +1 more
core
Transformation optics, isotropic chiral media and non-Riemannian geometry [PDF]
, 2011 Copyright © 2011 IOP Publishing Ltd and Deutsche Physikalische GesellschaftOpen Access journalArticle published under a Creative Commons Attribution 3.0 Unported (CC-BY) licenseThe geometrical interpretation of electromagnetism in transparent media ...
Horsley, S. A. R. +2 more
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Optical turbulence forecast in the Adaptive Optics realm
, 2018 Scientific drivers related to the optical turbulence forecast applied to the ground-based astronomy supported by Adaptive Optics, the state of the art of the achieved results and the most relevant challenges for future progresses are ...
TURCHI, ALESSIO +5 more
core +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source