Results 91 to 100 of about 7,000,091 (297)

Section on the special year for mathematics of planet earth (MPE 2013)

, 2012
Dozens of research centers, foundations, international organizations and scientific societies, including the Institute of Mathematical Statistics, have joined forces to celebrate 2013 as a special year for the Mathematics of Planet Earth.
Gneiting, Tilmann
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Multicenter study for CH-VAD as a fully magnetically levitated left ventricular assist device

iScience
Summary: The CH-VAD is a fully magnetically levitated left ventricular assist device (LVAD) designed for optimized hemocompatibility. This study evaluates the clinical outcomes of 77 patients implanted with the CH-VAD across seven centers in China from ...
Yifan Lu, Shuanglei Zhao, Jie Han, Qiang Lv, Xin Du, Zhengdong Hua, Keli Huang, Zhenwei Ge, Xiaoning Sun, Dan Zhu, Yongfeng Shao, Hongjia Zhang, Ming Gong   +12 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

The role of platelet-rich plasma in biomedicine: A comprehensive overview

iScience
Summary: Biomedicine has seen significant advancements in the 21st century, with platelet-rich plasma (PRP) playing a crucial role in clinical practice.
Zhixin Zhang, Peng Liu, Xinmiao Xue, Zhiyu Zhang, Li Wang, Yvke Jiang, Chi Zhang, Hanwen Zhou, Shuhan Lv, Weidong Shen, Shiming Yang, Fangyuan Wang   +11 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Basin dependencies of tropical cyclone genesis environment and possible future changes revealed by machine learning methods

iScience
Summary: Tropical cyclone (TC) genesis mechanisms remain debated, complicating predictions of climate change impacts. This study uses principal-component analysis (PCA), confidence ellipses, and correlation circles to analyze TC genesis environments ...
QiFeng Qian, YeFeng Chen, XiaoJing Jia, Hao Ma, Wei Dong   +4 more
doaj   +1 more source

The Relevance of Rigour for Design Practise [PDF]

, 2009
Design is an inverted discipline. The concept of rigour, as understood within the natural sciences, cannot be applied to Design Practice. Rigour for the natural sciences is a quality assurance mechanism ensuring that the knowledge bases of the ...
Spencer, Nick
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A contactless monitoring system for accurately predicting energy expenditure during treadmill walking based on an ensemble neural network

iScience
Summary: The monitoring of treadmill walking energy expenditure (EE) plays an important role in health evaluations and management, particularly in older individuals and those with chronic diseases.
Shangjun Huang, Houde Dai, Xiaoming Yu, Xie Wu, Kuan Wang, Jiaxin Hu, Hanchen Yao, Rui Huang, Wenxin Niu   +8 more
doaj   +1 more source