Results 91 to 100 of about 17,194,233 (248)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

A contactless monitoring system for accurately predicting energy expenditure during treadmill walking based on an ensemble neural network

iScience
Summary: The monitoring of treadmill walking energy expenditure (EE) plays an important role in health evaluations and management, particularly in older individuals and those with chronic diseases.
Shangjun Huang, Houde Dai, Xiaoming Yu, Xie Wu, Kuan Wang, Jiaxin Hu, Hanchen Yao, Rui Huang, Wenxin Niu   +8 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Roles and therapeutic opportunities of ω-3 long-chain polyunsaturated fatty acids in lung cancer

iScience
Summary: Over the past decades, researchers have continuously investigated the potential functions of long-chain polyunsaturated fatty acids (LCPUFAs) in cancers, including lung cancer.
Jiang Luo, Shu Peng, Ziyu Jiang, Qingwei Wang, Mini Zhang, Yuxin Zeng, Yu Yuan, Min Xia, Zixi Hong, Yufei Yan, Yushuang Tan, Jiawen Tang, Conghua Xie, Yan Gong   +13 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

PELIKAN – Developing International Game Development Education [PDF]

Kajaani University of Applied Sciences (KAMK) has been educating game industry professionals for almost 20 years. Education began in 2006 with game programming, and in 2009 it expanded to include game graphics, production, and design.
Helin, Tommi, Taipaleenmäki, Juho, Muhonen, Joonas, Sievers, Kirsi, Korhonen, Tanja, Kinnunen, Niko, Aihkisalo, Kiia   +6 more
core  

2020 Graduates. School of Applied Sciences

, 2021
The COVID-19 Pandemic delayed 2020 Commencement ceremonies until the following year. Dean of the School of Applied Sciences: Dr.
Grandjean, Peter W., University of Mississippi. School of Applied Sciences   +1 more
core   +1 more source

Cutting-edge microneedle innovations: Transforming the landscape of cardiovascular and metabolic disease management

iScience
Summary: Cardiovascular diseases (CVDs) and metabolic disorders (MDs) have surfaced as formidable challenges to global health, significantly imperiling human well-being. Recently, microneedles (MNs) have garnered substantial interest within the realms of
Xiaoning Zhang, Ming Li, Qiang Gao, Xiaoya Kang, Jingyao Sun, Yao Huang, Hong Xu, Jing Xu, Songren Shu, Jian Zhuang, Yuan Huang   +10 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Computer-aided robotics for applications in fracture reduction surgery: Advances, challenges, and opportunities

iScience
Summary: The advancement of information technology and AI has boosted global economic and social development. Robot systems (RS) and computer-aided technology (CAT) are used in various domains, including social production and human existence. Traditional
Xianzheng Zhou, Yimiao Chen, Genyuan Miao, Yanchao Guo, Qinhe Zhang, Jianping Bi   +5 more
doaj   +1 more source