Results 71 to 80 of about 7,000,091 (297)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Drug nanocrystals: Surface engineering and its applications in targeted delivery

iScience
Summary: Drug nanocrystals have received significant attention in drug development due to their enhanced dissolution rate and improved water solubility, making them effective in overcoming issues related to drug hydrophobicity, thereby improving drug ...
Phattalapol Lhaglham, Luksika Jiramonai, Yaru Jia, Baoying Huang, Yuanyu Huang, Xueyun Gao, Jinchao Zhang, Xing-Jie Liang, Mengliang Zhu   +8 more
doaj   +1 more source

Environmental sciences at universities of applied sciences

Chimia, 2018
Three institutes of the Universities of Applied Sciences that are active in Chemistry and Life Sciences present a selection of their activities in the field of environmental sciences. These projects include analytical monitoring, removal of micropollutants, waste reduction and valorization.
Simon Crelier, Olivier Vorlet, Philippe Corvini, Peter Lienemann   +3 more
openaire   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

“PyTDL”: A versatile temporal difference learning algorithm to simulate behavior process of decision making and cognitive learning

iScience
Summary: Humans and animals excel at learning complex tasks through reward-based feedback, dynamically adjusting value expectations and choices based on past experiences to optimize outcomes. However, understanding the hidden cognitive components driving
Qiyun Wu, Xiaodan Yang, Kaishu Wang, Min Zhu, Jiejunyi Liang, Yunyun Han   +5 more
doaj   +1 more source

Explanation and Understanding Revisited [PDF]

, 2017
"Explanation and Understanding" (1971) by Georg Henrik von Wright is a modern classic in analytic hermeneutics, and in the philosophy of the social sciences and humanities in general.
Raatikainen, Panu
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Following the robot’s lead: Predicting human and robot movement from EEG in a motor learning HRI task

iScience
Summary: A large proportion of human behavior is organized in time in the form of sensorimotor sequences. Learning new behavioral sequences recruits cognitive functions with their neural underpinnings.
Tanaya Chatterjee, Adrien Guzzo, Alejandro Tlaie, Ahmad Kaddour, Charalambos Papaxanthis, Jeremie Gaveau, Peter Ford Dominey   +6 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Advances of 3D bioprinting technology for periodontal tissue regeneration

iScience
Summary: 3D bioprinting technology for periodontal tissue regeneration is an advanced manufacturing technique that utilizes three-dimensional (3D) printing principles to fabricate intricate, viable structures that are specifically devised to meet with ...
Huanhuan Chen, Yu Wang, Yue Lai, Chenda Meng, Xiner Ning, Tianmin Xu, Guangying Song, Yunfan Zhang, Yifan Lin, Bing Han   +9 more
doaj   +1 more source