Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
iScienceSummary: Cost reductions are essential for accelerating clean technology deployment. Because multiple factors influence costs, traditional one-factor learning models, solely relying on cumulative installed capacity as an explanatory variable, may ...
Yoga W. Pratama +5 more
doaj +1 more source
A safe learning environment from the perspective of Laurea University of applied sciences safety, security and risk management students and staff. [PDF]
Heliyon, 2023 Savolainen T.
europepmc +1 more source
Preface: 2017 International Conference on Applied Mathematics and Computer Science (ICAMCS 2017) [PDF]
, 2017 openalex +1 more source
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
iScienceSummary: Pyrrolidine (PyD) has an important impact on the environment and human health. However, there is currently no method for trace detection of PyD. Here, we successfully designed diaminomethylene-4H-pyran (1) as the first specific fluorescent probe
Xi-Ying Cao +9 more
doaj +1 more source
Business as usual? Assessing the impact of the COVID-19 pandemic to research, development and innovation (RDI) activities of universities of applied sciences. [PDF]
Tert Educ Manag (Dordr), 2021 Salomaa M, Caputo A.
europepmc +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Shaping electrospray plume with convergent sound beams
iScienceSummary: Electrospray ionization (ESI) is one of the mainstream ionization techniques for mass spectrometry (MS) nowadays. Here, we present a new variant of ESI-MS setup, in which an electrospray emitter points to the mass spectrometer’s orifice while ...
Yu-Hao Chen +2 more
doaj +1 more source
Three possible applications of Neutrosophic Logic in Fundamental and Applied Sciences
, 2020 Victor Christianto +2 more
openalex +1 more source