Results 211 to 220 of about 16,264,514 (388)

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

PQR cascade: A system proposed for research prioritization in applied sciences. [PDF]

J Educ Health Promot
Rafiey H, Forouzan AS, Ahmadi S.
europepmc   +1 more source

The global development of applied community studies: Comparison and evaluation of trends in psychology, sociology, social work and other community sciences.

, 2018
Douglas D. Perkins
openalex   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Radiation-resistant bacteria in desiccated soil and their potentiality in applied sciences. [PDF]

Front Microbiol
Khan A, Liu G, Zhang G, Li X.
europepmc   +1 more source

BURNOUT LEVELS AMONG SENIOR STUDENTS IN APPLIED SCIENCES FACULTIES: AN EMPIRICAL ANALYSIS IN TURKEY

, 2016
Ramazan Erturgut, Hasan Emin Gürler
openalex   +2 more sources

Mathematical Methods in the Applied Sciences

Editorial Assistant, Editor-in-ChiEf, Associate Editor, Florida State University Wang, Founding Editors, Sales Department, 44 1243 770 254, 1243 770 432, Permissions, wiley.com, 2024, Texas AM University Agarwal, King Abdulaziz University Ahmad, University of KwaZulu-Natal Banasiak, Universidad de Alcalá Bravo, Warsaw University of Technology Chelminski, Guangdong University Chen, Politecnico di Milano Italy Colombo, Universidade Rodriguez Ramos University Cuevas, Federal de, University of Bari Italy D’Abbicco, Guelma University Algeria Debbouche, Fudan University of Shanghai Ding, Ovidius University of Constanţa Flaut, University of Sofia Georgiev, Universität des Saarlandes Groves, Bauhaus Universität Weimar Gürlebeck, Goethe University Frankfurt Harrach, East China University of Science and, I. of, China, Khalifa University United Arab Emirates Kirane, Center for Research and Kravchenko, Shanghai University China Li, Capital Normal University Li, Nanjing University Li, University of Maria Mariano, Leipzig University of Merker, Germany, University of Sharjah Messaoudi, Brunel University UK Mikhailov, Reinaldo, editors   +42 more
semanticscholar   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Coordinating Qualitative Predictor Variables in an Applied Linear Model: Analysis and Application for Applied Sciences. [PDF]

Cureus
Ahmad WMAW, Ahmed F, Adnan MN.
europepmc   +1 more source

Applying Science [PDF]

BioScience, 2017
openaire   +1 more source