Results 221 to 230 of about 11,545,650 (360)

Evaluation of Moodle Features at Kajaani University of Applied Sciences - Case Study

International Conference on Computer Science and Computational Intelligence, 2017
Deepak Kc
semanticscholar   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

DEPARTMENT OF APPLIED SCIENCE. Annual Report.

, 1969

openalex   +2 more sources

Mainzer: Symmetrien der Natur/Ludwig u Falter: Symmetries in Physics: Group Theory Applied to Physical Problems/Tayler: Sterne – Aufbau und Entwicklung/Tayler: Galaxien – Aufbau und Entwicklung/Peitgen u Saupe: The Science of Fractal Images/Penrose u Rindler: Spinors and space‐time, Vol. 2/Williams: Polarized Neutrons [PDF]

, 1989
T. Mayer‐Kuckuk, R. Zeller, M. Loewenhaupt, H. J. Haubold, S. Großmann, Cláus Lämmerzahl   +5 more
openalex   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

Molecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li, Zhijie Cao, Haiyan Xing, Zhenya Xue, Wenbing Liu, Jiayuan Chen, Yihan Mei, Runxia Gu, Hui Wei, Shaowei Qiu, Min Wang, Qing Rao, Jianxiang Wang   +12 more
wiley   +1 more source

Applied science to lose out in UK university subject reviews [PDF]

, 1988
Simon Hadlington
openalex   +1 more source

Advances in geometrical parametrization and reduced order models and methods for computational fluid dynamics problems in applied sciences and engineering: overview and perspectives

, 2016
Filippo Salmoiraghi, F. Ballarin, G. Corsi, A. Mola, M. Tezzele, G. Rozza   +5 more
semanticscholar   +1 more source

Unveiling unique protein and phosphorylation signatures in lung adenocarcinomas with and without ALK, EGFR, and KRAS genetic alterations

Molecular Oncology, EarlyView.
Proteomic and phosphoproteomic analyses were performed on lung adenocarcinoma (LUAD) tumors with EGFR, KRAS, or EML4–ALK alterations and wild‐type cases. Distinct protein expression and phosphorylation patterns were identified, especially in EGFR‐mutated tumors. Key altered pathways included vesicle transport and RNA splicing.
Fanni Bugyi, Mirjam Balbisi, Simon Sugár, Lóránd Váncza, Eszter Regős, Ilona Kovalszky, Ibolya Laczó, Tünde Harkó, Gábor Kecskeméti, Zoltán Szabó, Judit Moldvay, László Drahos, Lilla Turiák   +12 more
wiley   +1 more source

Higher education teachers’ descriptions of their own learning: a large-scale study of Finnish Universities of Applied Sciences

, 2016
Aija Töytäri, Arja Piirainen, P. Tynjälä, Liisa Vanhanen-Nuutinen, Kimmo Mäki, Vesa Ilves   +5 more
semanticscholar   +1 more source

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source