Results 71 to 80 of about 15,881,175 (390)
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
, 2011 This important book recognises that issues of religion and education in Europe need to be addressed in an interdisciplinary way. Not only do research methods from the social sciences and humanities need to be applied, but insights from a range of ...
Jackson, Robert
core
Introduction to Applied Data Science [PDF]
, 2019 What is data science? Attempts to define it can be made in one (prolonged) sentence, while it may take a whole book to demonstrate the meaning of this definition. This book introduces data science in an applied setting, by first giving a coherent overview of the background in Part I, and then presenting the nuts and bolts of the discipline by means of ...
Stadelmann, Thilo +2 more
openaire +1 more source
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Institutes of applied science [PDF]
Journal of the Franklin Institute, 1919 n ...
openaire +2 more sources
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
Drug nanocrystals: Surface engineering and its applications in targeted delivery
iScienceSummary: Drug nanocrystals have received significant attention in drug development due to their enhanced dissolution rate and improved water solubility, making them effective in overcoming issues related to drug hydrophobicity, thereby improving drug ...
Phattalapol Lhaglham +8 more
doaj +1 more source
Explanation and Understanding Revisited [PDF]
, 2017 "Explanation and Understanding" (1971) by Georg Henrik von Wright is a modern classic in analytic hermeneutics, and in the philosophy of the social sciences and humanities in general.
Raatikainen, Panu
core +1 more source
Mathematical modeling of Zika disease in pregnant women and newborns with microcephaly in Brazil
, 2017 We propose a new mathematical model for the spread of Zika virus. Special attention is paid to the transmission of microcephaly. Numerical simulations show the accuracy of the model with respect to the Zika outbreak occurred in Brazil.Comment: This is a ...
Area, Ivan +4 more
core +1 more source
Evolutionary interplay between viruses and R‐loops
FEBS Letters, EarlyView.Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi +4 more
wiley +1 more source