Results 71 to 80 of about 6,938,619 (347)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Targeting nanoparticles to lung cancer-derived A549 cells based on changes on interstitial stiffness in biomimetic models

iScience
Summary: The mechanical properties and forces of the extracellular environment modulate alveolar epithelial cell behavior. To model cancer/fibrosis associated stiffening and dynamic stretch, a biomimetic device was developed that imitates the active ...
Afia Ibnat Kohon, Kun Man, Ala Hessami, Katelyn Mathis, Jade Webb, Joanna Fang, Parsa Radfar, Yong Yang, Brian Meckes   +8 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Drug nanocrystals: Surface engineering and its applications in targeted delivery

iScience
Summary: Drug nanocrystals have received significant attention in drug development due to their enhanced dissolution rate and improved water solubility, making them effective in overcoming issues related to drug hydrophobicity, thereby improving drug ...
Phattalapol Lhaglham, Luksika Jiramonai, Yaru Jia, Baoying Huang, Yuanyu Huang, Xueyun Gao, Jinchao Zhang, Xing-Jie Liang, Mengliang Zhu   +8 more
doaj   +1 more source

Multiparametric in vivo ultrasound shear wave viscoelastography on farm-raised fatty duck livers: human radiology imaging applied to food sciences

, 2021
Manish Bhatt, Ladan Yazdani, François Destrempes, Louise Allard, Bich Nguyen, An Tang, Guy Cloutier   +6 more
openalex   +1 more source

The Relevance of Rigour for Design Practise [PDF]

, 2009
Design is an inverted discipline. The concept of rigour, as understood within the natural sciences, cannot be applied to Design Practice. Rigour for the natural sciences is a quality assurance mechanism ensuring that the knowledge bases of the ...
Spencer, Nick
core  

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

“PyTDL”: A versatile temporal difference learning algorithm to simulate behavior process of decision making and cognitive learning

iScience
Summary: Humans and animals excel at learning complex tasks through reward-based feedback, dynamically adjusting value expectations and choices based on past experiences to optimize outcomes. However, understanding the hidden cognitive components driving
Qiyun Wu, Xiaodan Yang, Kaishu Wang, Min Zhu, Jiejunyi Liang, Yunyun Han   +5 more
doaj   +1 more source

A review of instrumental variables estimation in the applied health sciences [PDF]

Health scientists often use observational data to estimate treatment effects when controlled experiments are not feasible. A limitation of observational research is non-random selection of subjects into different treatments, potentially leading to ...
Paul Grootendorst
core  

Forecasting and Forecast Combination in Airline Revenue Management Applications [PDF]

, 2008
Predicting a variable for a future point in time helps planning for unknown future situations and is common practice in many areas such as economics, finance, manufacturing, weather and natural sciences. This paper investigates and compares approaches
Gabrys, Bogdan, Lemke, Christiane
core