Results 91 to 100 of about 225,346 (288)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

The influence of cardiac synchronisation on self-attribution to external objects in male participants

Frontiers in Psychology
Interoception, the representation of our bodily state derived from physiological signals, is fundamental to our sense of self. Previous studies using cardiac feedback paradigms demonstrated interoceptive effects on self-perception.
Hiroshi Shibata, Tokiko Harada, Hideki Ohira   +2 more
doaj   +1 more source

Effects of optimism on creativity under approach and avoidance motivation

Frontiers in Human Neuroscience, 2014
Focusing on avoiding failure or negative outcomes (avoidance motivation) can undermine creativity, due to cognitive (e.g., threat appraisals), affective (e.g., anxiety), and volitional processes (e.g., low intrinsic motivation).
Tamar eIcekson, Marieke eRoskes, Simone eMoran   +2 more
doaj   +1 more source

The effects of approach-avoidance behaviors on goal appraisals [PDF]

Title from PDF of title page (University of Missouri--Columbia, viewed on Feb 15, 2010)The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.
Hicks, Joshua A.
core   +1 more source

Emotional Barriers to Job Search Success: Job Search Anxiety during University-to-Work Transitions [PDF]

, 2017
No abstract ...
Okay-Somerville, Belgin, Scholarios, Dora   +1 more
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

On the automatic link between affect and tendencies to approach and avoid: Chen and Bargh (1999) revisited.

Frontiers in Psychology, 2015
Within the literature on emotion and behavioral action, studies on approach-avoidance take up a prominent place. Several experimental paradigms feature successful conceptual replications but many original studies have not yet been replicated directly. We
Mark eRotteveel, Mark eRotteveel, Alex eGierholz, Gijs eKoch, Cherelle eVan Aalst, Yair ePinto, Yair ePinto, Dora eMatzke, Helen eSteingroever, Josine eVerhagen, Titia Francisca Beek, Ravi eSelker, Adam eSasiadek, Eric-Jan eWagenmakers, Eric-Jan eWagenmakers   +14 more
doaj   +1 more source

Achievement goals, self-handicapping, and performance: A 2 × 2 achievement goal perspective [PDF]

, 2009
Elliot and colleagues (2006) examined the effects of experimentally induced achievement goals, proposed by the trichotomous model, on self-handicapping and performance in physical education.
Adie J., Alison L. Smith, Atkinson J. W., Cecilie Th⊘gersen-Ntoumani, Cohen J., Conroy D. E., Conroy D. E., Duda J. L., Elliot A. J., Elliot A. J., Elliot A. J., Giannini J. M., Harackiewicz J. M., Nicholls J. G., Nikos Ntoumanis, Rhodewalt F., Rialland M., Roberts G. C.   +17 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Goal Orientations and Activation of Approach Versus Avoidance Motivation While Awaiting an Achievement Situation in the Laboratory

Frontiers in Psychology, 2018
While some students try to give their best in an achievement situation, others show disengagement and just want to get the situation over and done with. The present study investigates the role of students’ tendencies for approach or avoidance motivation ...
Sigrid Wimmer, Helmut K. Lackner, Ilona Papousek, Manuela Paechter   +3 more
doaj   +1 more source