Results 111 to 120 of about 225,346 (288)

The Potential Role of Temporal Dynamics in Approach Biases: Delay-dependence of a General Approach Bias in an Alcohol Approach-Avoidance Task

Frontiers in Psychology, 2014
Attractive cues have been shown to evoke automatic approach biases in tasks such as the Automatic Approach Task or Stimulus Response Compatibility task.
Thomas Edward Gladwin, Sören Erik Mohr, Reinout W Wiers   +2 more
doaj   +1 more source

Risk as reward: Reinforcement sensitivity theory and psychopathic personality perspectives on everyday risk-taking [PDF]

, 2018
This study updates and synthesises research on the extent to which impulsive and antisocial disposition predicts everyday pro- and antisocial risk-taking behaviour.
Andershed, Bacon, Blais, Byrd, Carroll, Carver, Clark, Corr, Corr, Corr, Corr, Corr, Corr, Corr, Drislane, Dunbar, Essau, Frick, Furr, Greene, Hall, Hare, Hepper, Heym, Hughes, Kimonis, Krstic, Lee, Levenson, Lilienfeld, Lilienfeld, Loeber, Lynam, Mann, Neumann, Patrick, Patrick, Pérez, Ray, Revelle, Roose, Satchell, Satchell, Sellbom, Shepherd, Simó, Sitney, Skeem, Soto, Wahlund, Wilson   +50 more
core   +4 more sources

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Maintenance of aversive memories shown by fear extinction-impaired phenotypes is associated with increased activity in the amygdaloid-prefrontal circuit [PDF]

, 2016
Although aversive memory has been mainly addressed by analysing the changes occurring in average populations, the study of neuronal mechanisms of outliers allows understanding the involvement of individual differences in fear conditioning and extinction.
Caioli, Silvia, De Bartolo, Paola, LARICCHIUTA, DANIELA, PETROSINI, Laura, Saba, Luana, Zona, Cristina   +5 more
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source

Social anxiety changes the way we move-A social approach-avoidance task in a virtual reality CAVE system.

PLoS ONE, 2019
Investigating approach-avoidance behavior regarding affective stimuli is important in broadening the understanding of one of the most common psychiatric disorders, social anxiety disorder.
Bastian Lange, Paul Pauli
doaj   +1 more source

Understanding Interest And Self-Efficacy In The Reading And Writing Of Students With Persisting Specific Learning Disabilities During Middle Childhood And Early Adolescence [PDF]

, 2017
Three methodological approaches were applied to understand the role of interest and self-efficacy in reading and/or writing in students without and with persisting specific learning disabilities (SLDs) in literacy.
Abbott, R., Beers, S., Berninger, V., Hidi, S. E., Mickail, T., Renninger, K. Ann, Richards, T.   +6 more
core   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Feeling good, approaching the positive

Frontiers in Psychology
IntroductionApproach and avoidance behaviors have been extensively studied in cognitive science as a fundamental aspect of human motivation and decision-making.
Kristina Kobrock, Johannes Solzbacher, Nicole Gotzner, Peter König, Peter König   +4 more
doaj   +1 more source