Results 121 to 130 of about 165,322 (267)

Acceptability and appropriateness of remote monitoring and self-administered pulse oximetry among COVID-19 patients in Honduras: a mixed-methods study. [PDF]

Prim Health Care Res Dev
Roberts KW, Alvarez B, Diaz O, de St Aubin M, Garnier S, Cruz S, Pavon L, Ochoa A, Solis S, Midence S, Mejía Santos H, Ochoa J, Dumas D, Baldwin M, Schnorr CD, Martinez A, Paina L, Nilles E.   +17 more
europepmc   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Clinical Evaluation of ChatGPT-5.3 Responses to Patient-Oriented Questions on Scoliosis: A Multidimensional Expert Analysis. [PDF]

Healthcare (Basel)
Doran M.
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Appropriateness and determinants of outpatient antibiotic use among migrants in British Columbia, Canada: a population-based study. [PDF]

JAC Antimicrob Resist
Chang CY, Chuang E, Thiruchelvam D, Patrick DM, Saatchi A, Lishman H, Brown K, Langford BJ, Leung V, Daneman N, Silverman M, Ramlackhan K, Schwartz KL, Marra F.   +13 more
europepmc   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Antibiotic appropriateness among patients experiencing homelessness at an interprofessional student-run free clinic. [PDF]

Antimicrob Steward Healthc Epidemiol
Laster O, Stewart MP, Lin KP, Carlson TJ.   +3 more
europepmc   +1 more source

Wholly appropriate [PDF]

British Dental Journal, 2010
openaire   +2 more sources

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Appropriateness of patients transferred with orthopaedic injuries: a retrospective study of a Level III teaching hospital. [PDF]

OTA Int
O'Brien C, Jelinek T, Young A, Phelps C, Patel A, Basener C, Scott J.   +6 more
europepmc   +1 more source