Results 211 to 220 of about 266,328 (249)

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Cell-based therapy injections for the management of knee osteoarthritis: The ESSKA-ICRS consensus. Recommendations using the RAND/UCLA appropriateness method for different clinical scenarios. [PDF]

Knee Surg Sports Traumatol Arthrosc
de Girolamo L, Kon E, Laver L, Andriolo L, Boffa A, Bagge J, Barfod KW, Bastos R, Cugat R, de Caro F, Di Martino A, Drobnič M, Espregueira-Mendes J, Iosifidis M, Kocaoglu B, Magalon J, Mangiavini L, Marinescu R, Nehrer S, Ostojić M, Sánchez M, Sas K, Skarpas G, Słynarski K, Snow M, Tischer T, Vonk L, Winkler T, Filardo G.   +28 more
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Evaluation of eradication efficacy and optimization strategies for <i>Helicobacter pylori</i> infection based on real-world data: a multivariable retrospective study. [PDF]

Front Med (Lausanne)
He Z, He L, Qu Y, Zheng Y, Dou L, Luo S, Ye Z, Huang C.   +7 more
europepmc   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Cultural adaptation and psychometric assessment of acceptability, appropriateness, and feasibility measures for family planning interventions among midwives and nurses in Ghana. [PDF]

Implement Sci Commun
Maya E, Guure C, Glozah FN, Sonalkar S, McAllister A, Doe R, Kiarie J, Gaffield ME.   +7 more
europepmc   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Evaluating the involvement of autolysosomes in the nuclear translocation of fluorescent proteins

FEBS Open Bio, EarlyView.
Endogenously expressed fluorescent proteins can be degraded by autophagy and transported to cell nuclei via the nuclear pore complex. But in some cell lines, for example, HeLa cells which are positive for immunoreactivity of a receptor ligand, such as UCN I, in cell nuclei, fusion of autolysosome with the nuclear envelope is involved in the nuclear ...
Keiichi Ikeda
wiley   +1 more source

Nonvalvular Atrial Fibrillation and Anticoagulation in the Elderly: A Retrospective Cohort Study. [PDF]

Cardiol Res
Jia K, Rimsky E, Noguer J, Sattarzadeh A, Shah S, Sherani MA, Khayat O, Abofrekha B, Lee UJ, El-Sayegh S.   +9 more
europepmc   +1 more source