Results 71 to 80 of about 742,791 (250)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Gearbox Fault Diagnosis based on LMD Approximate Entropy and PSO-ELM

Jixie chuandong, 2017
For the detection and identification problems of common faults in the use of gearbox,considering the nonlinear,non-stationary properties of the gearbox vibration response signal,a method for the gearbox fault diagnosis based on local mean decomposition ...
Zhang Yuxue, Pan Hongxia
doaj  

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Blind source separation to enhance spectral and non-linear features of magnetoencephalogram recordings:Application to Alzheimer's disease [PDF]

, 2009
This work studied whether a blind source separation (BSS) and component selection procedure could increase the differences between Alzheimer's disease (AD) patients and control subjects' spectral and nonlinear features of magnetoencephalogram (MEG ...
Abasolo, Daniel, Hornero, Roberto, Escudero, Javier; id_orcid, Fernandez, Alberto   +3 more
core   +1 more source

The Effect of Threshold Values and Weighting Factors on the Association between Entropy Measures and Mortality after Myocardial Infarction in the Cardiac Arrhythmia Suppression Trial (CAST)

Entropy, 2016
Heart rate variability (HRV) is a non-invasive measurement based on the intervals between normal heart beats that characterize cardiac autonomic function. Decreased HRV is associated with increased risk of cardiovascular events.
Christopher Mayer, Martin Bachler, Andreas Holzinger, Phyllis K. Stein, Siegfried Wassertheurer   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

‘Guide and Prejudice’— How Argonautes recognize targets across domains of life

FEBS Letters, EarlyView.
Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley   +1 more source

Credibility Assessment for Digital Twins in Vehicle-in-the-Loop Test Based on Information Entropy

Sensors
Digital twins in vehicle-in-the-loop (VIL) test has great practical significance for the functional development, testing and evaluation of intelligent vehicle.
Tianfang Gao, Liang Chen, Xinghui Zhang, Jinghua Guo, Dong Ni   +4 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Entropy - A Guide for the Perplexed [PDF]

, 2010
Entropy is ubiquitous in physics, and it plays important roles in numerous other disciplines ranging from logic and statistics to biology and economics.
Werndl, Charlotte, Charlotte Werndl, Frigg, Roman, Roman Frigg   +3 more
core