Results 91 to 100 of about 38,961 (295)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
, 2016 Relationship between HRV metrics (SDNN, RMSSD, total power, approximate entropy, sample entropy) and heart rate.
Syed Zaki Hassan Kazmi (2852093) +7 more
core +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Kashmir Journal of Science, 2022 The pulse oximeter signals have the potential to provide information about the functioning of the cardiorespiratory control system and its changing occurring due to aging and disease.
Naif Alharbi, Mohammed Alqahtani
doaj
, 2009 A multiple-degree-of-freedom artificial hand has been developed at the University of Southampton with the aim of including control philosophies to form a highly functional prosthesis hand.
Ahmad, Siti Anom
core
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Credibility Assessment for Digital Twins in Vehicle-in-the-Loop Test Based on Information Entropy
SensorsDigital twins in vehicle-in-the-loop (VIL) test has great practical significance for the functional development, testing and evaluation of intelligent vehicle.
Tianfang Gao +4 more
doaj +1 more source
Stress relaxation models with polyconvex entropy in Lagrangean and Eulerian coordinates
, 2013 The embedding of the equations of polyconvex elastodynamics to an augmented symmetric hyperbolic system provides in conjunction with the relative entropy method a robust stability framework for approximate solutions \cite{LT06}.
Tzavaras, Athanasios E.
core
Variable Selection Bias in Classification Trees Based on Imprecise Probabilities [PDF]
, 2005 Classification trees based on imprecise probabilities provide an advancement of classical classification trees. The Gini Index is the default splitting criterion in classical classification trees, while in classification trees based on imprecise ...
Carolin Strobl, Strobl, Carolin
core +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source